MRI guided focal HDR brachytherapy for localized prostate cancer : Toxicity, biochemical outcome and quality of life
- Maenhout, Metha
- Peters, Max
- Moerland, Marinus A
- Meijer, Richard P
- van den Bosch, Maurice A A J
- Frank, Steven J
- Nguyen, Paul L
- van Vulpen, Marco
- van der Voort van Zyp, Jochem R N
DOIAbstract
PURPOSE: To describe toxicity, biochemical outcome and quality of life after MRI guided focal high dose rate brachytherapy (HDR-BT) in a single fraction of 19 Gy for localized prostate cancer. MATERIALS AND METHODS: Between May 2013 and April 2016, 30 patients were treated by MRI-guided focal HDR-BT. Patients with visible tumour on MRI were included. All patients were ≥65 years, T-stage <T3, Gleason ≤7, PSA <10 ng/mL and IPSS <15. Focal irradiation was delivered in a single fraction of 19 Gy to the D95 of the clinical target volume. Toxicity was reported using the Common Terminology Criteria for Adverse Events version 4. Biochemical failure was defined according to the Phoenix criteria and quality of life was measured using validated questi...
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