Preterm Infants with Biliary Atresia : A Nationwide Cohort Analysis from the Netherlands
- Van Wessel, Daan B.E.
- Boere, Thomas
- Hulzebos, Christian V.
- de Kleine, Ruben H J
- Verkade, Henkjan J.
- Hulscher, Jan B F
- the Netherlands Study group of Biliary Atresia, Registry (NeSBAR)
DOIAbstract
Objectives: Biliary atresia (BA) occurs in 0.54 of 10.000 of overall live births in the Netherlands. BA has an unfavorable prognosis: <40% of patients are cleared of jaundice after Kasai portoenterostomy (KPE), 4-year transplant-free survival rate is 46% and the 4-year survival rate is ∼75%. Little is known on difficulties in diagnosis and the outcome of BA in preterm infants. We aimed to analyze the incidence and outcome of BA in preterm infants in the Netherlands. Methods: Retrospective study including Dutch preterm infants treated for BA. Parameters included gestational age, congenital anomalies, age at KPE, days between first symptoms, and KPE and referral interval (first hospital to KPE). Outcome parameters were clearance of jaundice (...
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