Biomarkers of folate and vitamin B12 and breast cancer risk : Report from the EPIC cohort
- Matejcic, M.
- de Batlle, J.
- Ricci, C.
- Biessy, C.
- Perrier, F.
- Huybrechts, I.
- Weiderpass, E.
- Boutron-Ruault, M. C.
- Cadeau, C.
- His, M.
- Cox, D. G.
- Boeing, H.
- Fortner, R. T.
- Kaaks, R.
- Lagiou, P.
- Trichopoulou, A.
- Benetou, V.
- Tumino, R.
- Panico, S.
- Sieri, S.
- Palli, D.
- Ricceri, F.
- Bueno-de-Mesquita, H. Bas
- Skeie, G.
- Amiano, P.
- Sánchez, M. J.
- Chirlaque, M. D.
- Barricarte, A.
- Quirós, J. R.
- Buckland, G.
- van Gils, C. H.
- Peeters, P. H.
- Key, T. J.
- Riboli, E.
- Gylling, B.
- Zeleniuch-Jacquotte, A.
- Gunter, M. J.
- Romieu, I.
- Chajès, V.
DOIAbstract
Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (ER, PR, and HER2), alcohol intake, and MTHFR polymorphisms (677C>T and 129...
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