Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P <5 x 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect ...
International audienceBody fat distribution is a heritable trait and a well-established predictor of...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
International audienceBody fat distribution is a heritable trait and a well-established predictor of...
International audienceBody fat distribution is a heritable trait and a well-established predictor of...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
International audienceBody fat distribution is a heritable trait and a well-established predictor of...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
International audienceBody fat distribution is a heritable trait and a well-established predictor of...
International audienceBody fat distribution is a heritable trait and a well-established predictor of...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
International audienceBody fat distribution is a heritable trait and a well-established predictor of...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...