Report on the Clinical Outcomes of Permanent Breast Seed Implant for Early-Stage Breast Cancers

Purpose: Permanent breast seed implant is an accelerated partial breast irradiation technique realizing the insertion of 103 Pd seeds in the seroma after lumpectomy. We report the 5-year efficacy and tolerance for a cohort, pooling patients from 3 clinical trials. Methods and Materials: The trials accrued postmenopausal patients with infiltrating ductal carcinoma or ductal carcinoma in situ Results: The cohort included 134 patients, and the observed local recurrence rate at a median follow-up period of 63 months was 1.2% +/- 1.2%, similar to the estimate for whole breast irradiation (P=.23), significantly better than for surgery alone (relative risk 0.27; P Conclusions: The 5-year data suggest that permanent breast seed implantation is a safe accelerated partial breast irradiation option after lumpectomy for early-stage breast cancer with a tolerance profile similar to that of whole breast irradiation. (C) 2015 Elsevier Inc. All rights reserved