Tanzawaic acids isolated from a marine-derived fungus of the genus Penicillium with cytotoxic activities

Tanzawaic acids M (1), N (2), O (3) and P (4) and the known tanzawaic acids B (5) and E (6), have been isolated from an extract of a cultured marine-derived fungus (strain CF07370) identified as a member of the genus Penicillium. The structures of 1–4 were determined based on spectroscopic evidence. The antimicrobial and cytotoxic activities of compounds 1–6 were evaluated.This work was supported by the Ministerio de Ciencia e Innovación SAF2009–0839. F. C. acknowledges financial support from Programa JAE-Pre (CSIC). ARDM acknowledges funding from the IMBRAIN project (FP7-REGPOT-2012-CT2012–31637-IMBRAIN). CC is supported by a “Waxweiler grant for cancer prevention research” from the Action Lions “Vaincre le Cancer”, Luxembourg. This work was supported by Télévie Luxembourg, the “Recherche Cancer et Sang” foundation and “Recherches Scientifiques Luxembourg” association. The authors thank the “Een Häerz fir Kriibskrank Kanner” association and the Action Lions “Vaincre le Cancer” for generous support. MD is supported by the National Research Foundation (NRF) by the MEST of Korea for Tumor Microenvironment Global Core Research Center (GCRC) grant, [grant number 2012–0001184].Peer Reviewe