High-throughput nucleotide sequencing (often referred to as next-generation sequencing; NGS) is increasingly being chosen as a diagnostic tool for cases of expected but unresolved genetic origin. When exploring a higher number of genetic variants, there is a higher chance of detecting unsolicited findings. The consequential increased need for decisions on disclosure of these unsolicited findings poses a challenge for the informed consent procedure. This article discusses the ethical and practical dilemmas encountered when contemplating informed consent for NGS in diagnostics from a multidisciplinary point of view. By exploring recent similar experiences with unsolicited findings in other settings, an attempt is made to describe what can be ...
This is the author accepted manuscript. The final version is available from Nature Publishing Group ...
Cancer patients participating in studies involving experimental or diagnostic next-generation sequen...
PURPOSE: Little is known about how health-care professionals communicate with patients about consent...
High-throughput nucleotide sequencing (often referred to as next-generation sequencing; NGS) is incr...
ABSTRACT: High-throughput nucleotide sequencing (often referred to as next-generation sequencing; NG...
Unsolicited findings in genetic testing are disease causing variants which are unintentionally found...
Implementation of next-generation DNA sequencing (NGS) technology into routine diagnostic genome car...
The use of genome-wide sequencing (GWS) in paediatrics has added complexity to informed consent (IC)...
The disclosure of incidental findings, also called unsolicited findings, unexpected results, and sec...
Unsolicited findings (UFs) from diagnostic genetic testing are a subject of debate. The emerging con...
Background While integrating genomic sequencing into clinical care carries clear medical benefits, i...
textabstractCancer patients participating in studies involving experimental or diagnostic next-gener...
INTRODUCTION: Obtaining informed consent from prospective participants for research studies that inc...
The wider availability of genomic sequencing, notably gene panels, in cancer care allows for persona...
Introduction: Next-generation sequencing (NGS) is transforming the conduct of genetic research and d...
This is the author accepted manuscript. The final version is available from Nature Publishing Group ...
Cancer patients participating in studies involving experimental or diagnostic next-generation sequen...
PURPOSE: Little is known about how health-care professionals communicate with patients about consent...
High-throughput nucleotide sequencing (often referred to as next-generation sequencing; NGS) is incr...
ABSTRACT: High-throughput nucleotide sequencing (often referred to as next-generation sequencing; NG...
Unsolicited findings in genetic testing are disease causing variants which are unintentionally found...
Implementation of next-generation DNA sequencing (NGS) technology into routine diagnostic genome car...
The use of genome-wide sequencing (GWS) in paediatrics has added complexity to informed consent (IC)...
The disclosure of incidental findings, also called unsolicited findings, unexpected results, and sec...
Unsolicited findings (UFs) from diagnostic genetic testing are a subject of debate. The emerging con...
Background While integrating genomic sequencing into clinical care carries clear medical benefits, i...
textabstractCancer patients participating in studies involving experimental or diagnostic next-gener...
INTRODUCTION: Obtaining informed consent from prospective participants for research studies that inc...
The wider availability of genomic sequencing, notably gene panels, in cancer care allows for persona...
Introduction: Next-generation sequencing (NGS) is transforming the conduct of genetic research and d...
This is the author accepted manuscript. The final version is available from Nature Publishing Group ...
Cancer patients participating in studies involving experimental or diagnostic next-generation sequen...
PURPOSE: Little is known about how health-care professionals communicate with patients about consent...