Tumor growth involves a dynamic interplay between cancer cells and host cells, which collectively form a tumor microenvironmental network that either suppresses or promotes tumor growth under different conditions. The transition from tumor suppression to tumor promotion is mediated by a tumor-induced shift in the local immune state, and despite the clinical challenge this shift poses, little is known about how such dysfunctional immune states are initiated. Clinical and experimental observations have indicated that differences in both the composition and spatial distribution of different cell types and/or signaling molecules within the tumor microenvironment can strongly impact tumor pathogenesis and ultimately patient prognosis. How such “...
Due to tumor heterogeneity, most believe that effective treatments should be tailored to the feature...
Tumor microenvironments contain multiple cell types interacting among one another via different sign...
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibit...
Cancer is the second leading cause of death globally. Tumors form intricate ecosystems in which mali...
In this paper, we carry out an examination of four mechanisms that can potentially lead to changing ...
Breast cancer is a highly heterogeneous disease, having not only several intrinsic sub-types but als...
Cancer constantly evolves to evade the host immune system and resist different treatments. As a cons...
Intratumoral heterogeneity (ITH) has been regarded as a key cause of the failure and resistance of c...
Developing drugs increasingly relies on mechanistic modeling and simulation. Models that capture cau...
A major barrier for broadening the efficacy of immunotherapies for cancer is identifying key mechani...
Background It is now clearly evident that cancer outcome and response to therapy is ...
Spatial interactions between cancer and immune cells, as well as the recognition of tumour antigens ...
In the microenvironment of a malignancy, tumor cells do not exist in isolation, but rather in a dive...
The composition of the tumor microenvironment (TME)–the malignant, immune, and stromal cells implica...
Background: The advent of rapid and inexpensive sequencing technology allows scientists to decipher ...
Due to tumor heterogeneity, most believe that effective treatments should be tailored to the feature...
Tumor microenvironments contain multiple cell types interacting among one another via different sign...
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibit...
Cancer is the second leading cause of death globally. Tumors form intricate ecosystems in which mali...
In this paper, we carry out an examination of four mechanisms that can potentially lead to changing ...
Breast cancer is a highly heterogeneous disease, having not only several intrinsic sub-types but als...
Cancer constantly evolves to evade the host immune system and resist different treatments. As a cons...
Intratumoral heterogeneity (ITH) has been regarded as a key cause of the failure and resistance of c...
Developing drugs increasingly relies on mechanistic modeling and simulation. Models that capture cau...
A major barrier for broadening the efficacy of immunotherapies for cancer is identifying key mechani...
Background It is now clearly evident that cancer outcome and response to therapy is ...
Spatial interactions between cancer and immune cells, as well as the recognition of tumour antigens ...
In the microenvironment of a malignancy, tumor cells do not exist in isolation, but rather in a dive...
The composition of the tumor microenvironment (TME)–the malignant, immune, and stromal cells implica...
Background: The advent of rapid and inexpensive sequencing technology allows scientists to decipher ...
Due to tumor heterogeneity, most believe that effective treatments should be tailored to the feature...
Tumor microenvironments contain multiple cell types interacting among one another via different sign...
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibit...