CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual
- Oh, Djin-Ye
- Jessen, Heiko
- Kücherer, Claudia
- Neumann, Konrad
- Oh, Nari
- Poggensee, Gabriele
- Bartmeyer, Barbara
- Jessen, Arne
- Pruss, Axel
- Schumann, Ralf R.
- Hamouda, Osamah
DOIAbstract
Background: Homozygosity (Δ32/Δ32) for the 32 bp deletion in the chemokine receptor 5 (CCR5) gene is associated with strong resistance against HIV infection. Heterozygosity is associated with protection of HIV-1 disease progression. Methodology/Principal Findings: We genotyped a population of 737 HIV-positive adults and 463 healthy controls for the CCR5Δ32 deletion and found heterozygous frequencies of 16.2% (HIV-negative) and 17.5% (HIV-positive) among Caucasian individuals. Analysis of CCR5Δ32 influence on disease progression showed notably lower viral setpoints and a longer time to a CD4 count o
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