Structure and functions of glutathione S-transferase Pl-1

Glutathione S-transferase Pl-1 (GSTP1-1) is a multifunctional enzyme which protects the cell from the influence of genotoxic factors and apop-tosis. Contemporary knowledge about the GSTP1 molecule structure and the enzyme functions are summarized in this review. Also PI isoform is compared to other glutathione S-transferases and structure-function relationships are emphasized. Novel functions of GSTP1 in cell signaling modulation, NO storage and metabolism are highlighted in this paper