t(7;14)(q34;q11) TRA/TRB

Translocations and inversions involving the TRA/TRD locus at 14q11.2 and the TRB locus at 7q34 are characteristic anomalies in T-cell acute leukemia/lymphoma. In most instances, juxtaposing promoter and enhancer elements of TCR genes in the proximity of a partner gene results in their dysregulation that may be a critical step toward development of T-cell malignancies