t(3;17)(q26;q12-21) TBL1XR1/RARA

In classic APL (acute promyelocytic leukemia), the central leukemia-initiating event is the fusion between the promyelocytic leukemia (PML) and the retinoic acid receptor alpha (RARA) gene, that arise as a result of t(15;17)(q22;q21) chromosomal translocation. In variant forms of APL, RARA gene have other translocation partners than PML resulting in various molecular characteristics and sensitivities to all-trans-retinoic acid (ATRA) therapy. The variant t(3;17)(q26;q21) translocation, in whic