t(1;17)(p34;q21) IRF2BP2/RARA

Acute promyelocytic leukemia (APL) is characterized by the clonal expansion of myeloid precursors blocked at promyelocytic stage and the presence of t(15;17)(q24;q21) resulting in the fusion of retinoic acid receptor alpha (RARA) gene on 17q21.1 with promyelocytic leukemia (PML) gene at 15q24.1, and less frequently with other gene partners. Fusion between RARA and the interferon regulatory factor 2 binding protein 2 (IRF2BP2) genes is a rare variant translocation in APL