In some highly demanding fluid dynamics simulations, as for instance in inertial confinement fusion applications, it appears necessary to simulate multi-fluid flows involving numerous constraints at the same time, such as (and non-limitatively): large number of fluids (typically 10 and above), both isentropic and strongly shocked compressible evolution, large heat sources, large deformations, transport over large distances, and highly variable or contrasted EOS (equation of state) stiffnesses. Fulfilling such a challenge in a robust and tractable way demands that thermodynamic consistency of the numerical scheme be carefully ensured. This is addressed here over an arbitrarily evolving computational grid (ALE or Arbitrary Lagrangian?Eulerian...