Add to ORKGA range of aryl substituted spirocycles containing the indole moiety have been assembled through Claisen rearrangement, Fischer indole cyclization, ring-closing metathesis and the Suzuki-Miyaura cross-coupling reactions. Some of these molecules contain either a spirocyclic system or an indeno[1,2-b] indole framework, which is present in diverse bioactive targets. Here, we have used simple and readily available starting materials to generate a library of spirocycles with an indole unit in their structures. (C) 2014 Elsevier Ltd. All rights reserved
Unfunctionalized indoles can be directly converted into 3,3′-spirocyclic indolenines and indolines u...
Unfunctionalized indoles can be directly converted into 3,3'-spirocyclic indolenines and indolines u...
A modular and streamlined synthetic strategy for the generation of bridged indole alkaloid-like hete...
This Thesis describes efforts to develop improved methods to synthesise spirocyclic scaffolds based ...
In this account we disclose a variety of simple strategies demonstrated in our laboratory in the las...
Spiroindolines and spiroindoles are an important class of spirocyclic compounds present in a wide ra...
ABSTRACT: A concise synthesis of spiro-cyclopropane compounds from indole derivatives and sulfur yli...
Indole-ynones have been established as general substrates for radical dearomatizing spirocyclization...
We have demonstrated a simple and an efficient method for the synthesis of spirocycles starting with...
A simple and efficient method for the synthesis of highly substituted spiroindoline derivatives is p...
A high-yielding fast spirocyclization of easily available indol ynones has been developed by applyin...
A concise synthesis of spiro-cyclopropane compounds from indole derivatives and sulfur ylides has be...
A modular and streamlined synthetic strategy for the generation of bridged indole alkaloid-like hete...
Spirocyclic indole derivatives are fascinating tridimensional molecular scaffolds, from both a synth...
Nitrogen-containing heterocylces such as indoles, pyrroloindolines and spiropyrans are a common mot...
Unfunctionalized indoles can be directly converted into 3,3′-spirocyclic indolenines and indolines u...
Unfunctionalized indoles can be directly converted into 3,3'-spirocyclic indolenines and indolines u...
A modular and streamlined synthetic strategy for the generation of bridged indole alkaloid-like hete...
This Thesis describes efforts to develop improved methods to synthesise spirocyclic scaffolds based ...
In this account we disclose a variety of simple strategies demonstrated in our laboratory in the las...
Spiroindolines and spiroindoles are an important class of spirocyclic compounds present in a wide ra...
ABSTRACT: A concise synthesis of spiro-cyclopropane compounds from indole derivatives and sulfur yli...
Indole-ynones have been established as general substrates for radical dearomatizing spirocyclization...
We have demonstrated a simple and an efficient method for the synthesis of spirocycles starting with...
A simple and efficient method for the synthesis of highly substituted spiroindoline derivatives is p...
A high-yielding fast spirocyclization of easily available indol ynones has been developed by applyin...
A concise synthesis of spiro-cyclopropane compounds from indole derivatives and sulfur ylides has be...
A modular and streamlined synthetic strategy for the generation of bridged indole alkaloid-like hete...
Spirocyclic indole derivatives are fascinating tridimensional molecular scaffolds, from both a synth...
Nitrogen-containing heterocylces such as indoles, pyrroloindolines and spiropyrans are a common mot...
Unfunctionalized indoles can be directly converted into 3,3′-spirocyclic indolenines and indolines u...
Unfunctionalized indoles can be directly converted into 3,3'-spirocyclic indolenines and indolines u...
A modular and streamlined synthetic strategy for the generation of bridged indole alkaloid-like hete...