Comparison of the effect of trisodium phosphonoformate on the mean plaque size of pseudorabies virus, infectious bovine rhinotracheitis virus and pigeon herpesvirus

peer reviewedThe effect of various concentrations of trisodium phosphonoformate on the titre and the mean plaque of pseudorabies virus (SHS), infectious bovine rhinotracheitis (IBR) virus and pigeon herpesvirus (PHV) was studied. Phosphonoformate significantly reduced the mean plaque size of all three viruses whatever the concentration used. However, an increase of the concentration of phosphonoformate over 100 µM per ml in the overlay medium did not further reduce the mean plaque size of PHV. Phosphonoformate also produced a decrease in the titre of the three viruses at the highest concentration. SHV was the most susceptible to the effect of trisodium Phosphonoformate and PHV was the least susceptible. This finding might be of signifiance for a possible clinical application in the treatment of local lesions produced by PHV infection