Add to ORKGDopamiini funktsiooni on seostatud motivatsiooni ja meeleoluhäiretega. Käesolev töö uurib GDNF geeni ekspressiooni tõstmise mõju dopamiini tasemetele erineva uudistamisaktiivsusega rottide näitel. Rottide (n=37) ajukoes sisalduvat dopamiinitaset mõõdeti kõrgrõhuvedelikkromatograafia abil. Selgus, et väheuudistavatel rottidel tõusis olulisel määral dopamiini metaboliidi DOPAC tasemed nii juttkehas kui ka naalduvas tuumas GDNF geeni manipulatsiooni tulemusena, samas ei muutnud GDNF geeni manipulatsioon oluliselt dopamiini tasemed. Samuti leiti oluline erinevus dopamiini käives. Seega võib järeldada, et väheuudistavatel rottidel mõjutab GDNF dopamiini metabolismi
Parkinson's disease is a progressive degenerative brain disease that causes degeneration of dopamine...
The nucleus accumbens (NAc) is located in the ventral striatum and plays a critical role in drug add...
The neurotransmitter dopamine is involved in the regulation of diverse functions of the nervous syst...
Käesoleva töö eesmärgiks oli uurida neuropeptiid S-i (NPS) mõju erinevusi kõrge (high exploratory -...
Amphetamine and its derivatives are widely used as medicines but also abused as psychostimulant drug...
Parkinson's disease is a neurodegenerative disorder where dopaminergic neurons in substantia nigra a...
Part I: Parkinson's disease is a slowly progressive neurodegenerative disorder in which particularly...
Parkinson’s disease (PD) is a common neurodegenerative disorder, primarily characterized by the loss...
Main cellular pathologies of Parkinson’s disease are demise of midbrain dopamine neurons and abnorma...
Belohnungsassoziierte Lernprozesse lösen in kortikalen und subkortikalen Hirnstrukturen Aktivierunge...
Käesoleva töö eesmärgiks oli uurida erinevusi kõrge ja madala uudistamisaktiivsusega rottide sotsiaa...
Parkinson s disease (PD) is a neurodegenerative disorder associated with a progressive loss of dopam...
This review focuses on neurotrophic factors, especially CDNF, and Amyotropic lateral sclerosis (ALS)...
A hiper estimulação do sistema glutamatérgico (excitotoxicidade), é um evento tóxico para o sistema ...
In the written part of my master -thesis I discuss about GDNF signalling and more specifically how t...
Parkinson's disease is a progressive degenerative brain disease that causes degeneration of dopamine...
The nucleus accumbens (NAc) is located in the ventral striatum and plays a critical role in drug add...
The neurotransmitter dopamine is involved in the regulation of diverse functions of the nervous syst...
Käesoleva töö eesmärgiks oli uurida neuropeptiid S-i (NPS) mõju erinevusi kõrge (high exploratory -...
Amphetamine and its derivatives are widely used as medicines but also abused as psychostimulant drug...
Parkinson's disease is a neurodegenerative disorder where dopaminergic neurons in substantia nigra a...
Part I: Parkinson's disease is a slowly progressive neurodegenerative disorder in which particularly...
Parkinson’s disease (PD) is a common neurodegenerative disorder, primarily characterized by the loss...
Main cellular pathologies of Parkinson’s disease are demise of midbrain dopamine neurons and abnorma...
Belohnungsassoziierte Lernprozesse lösen in kortikalen und subkortikalen Hirnstrukturen Aktivierunge...
Käesoleva töö eesmärgiks oli uurida erinevusi kõrge ja madala uudistamisaktiivsusega rottide sotsiaa...
Parkinson s disease (PD) is a neurodegenerative disorder associated with a progressive loss of dopam...
This review focuses on neurotrophic factors, especially CDNF, and Amyotropic lateral sclerosis (ALS)...
A hiper estimulação do sistema glutamatérgico (excitotoxicidade), é um evento tóxico para o sistema ...
In the written part of my master -thesis I discuss about GDNF signalling and more specifically how t...
Parkinson's disease is a progressive degenerative brain disease that causes degeneration of dopamine...
The nucleus accumbens (NAc) is located in the ventral striatum and plays a critical role in drug add...
The neurotransmitter dopamine is involved in the regulation of diverse functions of the nervous syst...