The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity of INH can be enhanced by augmenting the hydrophilic INH into a hydrophobic/lipophilic compound. Therefore, a series of 13 derivatives with different hydrophobicity were synthesized by adding different hydrophobic acyl chain to the parent compound, INH
The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to trea...
Objective: The aim of this study was to the synthesis of indole, coumarinyl and pyridinyl derivative...
Tuberculosis (TB) is a chronic disease as a result of Mycobacterium tuberculosis. It can affect all ...
Funding Information: Financed by Fundação para a Ciência e a Tecnologia, I.P./MCTES through national...
The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has been...
AbstractThe synthesis of some new 3,4-disubstituted thiazolylideneisonicotinohydrazide derivatives 3...
Isoniazid (INH) is one of the key molecules employed in the treatment of tuberculosis (TB), the most...
Isoniazid is a first-line drug used against tuberculosis. It is a bactericidal drug with a selectivi...
Tuberculosis remains a leading cause of mortality among infectious diseases worldwide, prompting the...
Isoniazid (INH) is one of the two most effective first-line antitubercular drugs and is still used a...
International audienceTuberculosis remains a leading cause of mortality among infectious diseases wo...
The molecular properties of compounds expressing growth inhibition of Mycobacterium tuberculosis are...
Background: Hydrazones belonging to azomethine class of compounds have attracted the attention of ma...
The enzymes involved in the biosynthetic pathways of the critical components including mycolic acids...
Isoniazid (INH), one of two first-line drugs used to treat tuberculosis (TB), has been shown to be a...
The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to trea...
Objective: The aim of this study was to the synthesis of indole, coumarinyl and pyridinyl derivative...
Tuberculosis (TB) is a chronic disease as a result of Mycobacterium tuberculosis. It can affect all ...
Funding Information: Financed by Fundação para a Ciência e a Tecnologia, I.P./MCTES through national...
The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has been...
AbstractThe synthesis of some new 3,4-disubstituted thiazolylideneisonicotinohydrazide derivatives 3...
Isoniazid (INH) is one of the key molecules employed in the treatment of tuberculosis (TB), the most...
Isoniazid is a first-line drug used against tuberculosis. It is a bactericidal drug with a selectivi...
Tuberculosis remains a leading cause of mortality among infectious diseases worldwide, prompting the...
Isoniazid (INH) is one of the two most effective first-line antitubercular drugs and is still used a...
International audienceTuberculosis remains a leading cause of mortality among infectious diseases wo...
The molecular properties of compounds expressing growth inhibition of Mycobacterium tuberculosis are...
Background: Hydrazones belonging to azomethine class of compounds have attracted the attention of ma...
The enzymes involved in the biosynthetic pathways of the critical components including mycolic acids...
Isoniazid (INH), one of two first-line drugs used to treat tuberculosis (TB), has been shown to be a...
The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to trea...
Objective: The aim of this study was to the synthesis of indole, coumarinyl and pyridinyl derivative...
Tuberculosis (TB) is a chronic disease as a result of Mycobacterium tuberculosis. It can affect all ...