A clinically reflective model of the human colon was used to investigate the effects of the broad-spectrum antibiotic omadacycline on the gut microbiome, and subsequent potential to induce simulated Clostridium difficile infection (CDI). Triple stage chemostat gut models were inoculated with pooled human faecal slurry from healthy volunteers (age ≥60 years). Models were challenged twice with 107 cfu C. difficile spores (PCR ribotype 027). Omadacycline effects were assessed in a single gut model. Observations were confirmed in a parallel study with omadacycline and moxifloxacin. Antibiotic instillation was performed once daily for 7 days. The models were observed for 3 weeks post-antibiotic challenge. Gut microbiota populations and C. diffic...
8 pages, 4 figures, 1 tableauInternational audienceThe gastrointestinal tract is a complex ecosystem...
Treatment options for Clostridium difficile infection (CDI) remain limited despite this usually noso...
Background: Clostridioides difficile infection (CDI) has a high recurrent infection rate. Faecal mi...
Clostridium difficile infections are an emerging health problem in the modern hospital environment. ...
Clostridium difficile infections are an emerging health problem in the modern hospital environment. ...
© The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimic...
Background and aims Clostridium difficile infection (CDI) remains a healthcare burden and recurrent...
Objectives The use of broad-spectrum cephalosporins is associated with induction of Clostridioides ...
ABSTRACTBroad-spectrum antibiotics are often associated with a relatively high risk of Clostridium d...
Clostridium difficile infection is a frequent complication of antibiotic therapy in hospitalised pat...
Objectives: Clostridium difficile infection (CDI) is a major cause of morbidity in the nosocomial en...
Background Clostridioides difficile infection (CDI) remains a high burden worldwide. DAV131A, a nov...
<div><p><i>Clostridium difficile</i> infections are an emerging health problem in the modern hospita...
Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life th...
Data on the risk of Clostridium difficile infection (CDI) associated with specific antibiotics are d...
8 pages, 4 figures, 1 tableauInternational audienceThe gastrointestinal tract is a complex ecosystem...
Treatment options for Clostridium difficile infection (CDI) remain limited despite this usually noso...
Background: Clostridioides difficile infection (CDI) has a high recurrent infection rate. Faecal mi...
Clostridium difficile infections are an emerging health problem in the modern hospital environment. ...
Clostridium difficile infections are an emerging health problem in the modern hospital environment. ...
© The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimic...
Background and aims Clostridium difficile infection (CDI) remains a healthcare burden and recurrent...
Objectives The use of broad-spectrum cephalosporins is associated with induction of Clostridioides ...
ABSTRACTBroad-spectrum antibiotics are often associated with a relatively high risk of Clostridium d...
Clostridium difficile infection is a frequent complication of antibiotic therapy in hospitalised pat...
Objectives: Clostridium difficile infection (CDI) is a major cause of morbidity in the nosocomial en...
Background Clostridioides difficile infection (CDI) remains a high burden worldwide. DAV131A, a nov...
<div><p><i>Clostridium difficile</i> infections are an emerging health problem in the modern hospita...
Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life th...
Data on the risk of Clostridium difficile infection (CDI) associated with specific antibiotics are d...
8 pages, 4 figures, 1 tableauInternational audienceThe gastrointestinal tract is a complex ecosystem...
Treatment options for Clostridium difficile infection (CDI) remain limited despite this usually noso...
Background: Clostridioides difficile infection (CDI) has a high recurrent infection rate. Faecal mi...