Background: Eosinophils play an important role in the pathophysiology of asthma being implicated in airway epithelial damage and airway wall remodeling. We determined the genes associated with airway remodeling and eosinophilic inflammation inpatients with asthma. Methods: We analyzed the transcriptomic data from bronchial biopsies of 81 patients with moderate‐to‐severe asthma of the U‐BIOPRED cohort. Expression profiling was performed using Affymetrix arrays on total RNA. Transcription binding site analysis used the PRIMA algorithm. Localization of proteins was by immunohistochemistry. Results: Using stringent false discovery rate analysis, MMP‐10 and MET were significantly overexpressed in biopsies with high mucosal eosinophils (HE) compa...
Airway remodeling is a hallmark feature of asthma, and one of its key structural changes is increase...
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lu...
Background: Airway smooth muscle (ASM) remodeling is an important component of the structural change...
Background: Eosinophils play an important role in the pathophysiology of asthma being implicated in ...
Background Eosinophils play an important role in the pathophysiology of asthma being implicated in a...
BackgroundEosinophilia is a marker of corticosteroid responsiveness and risk of exacerbation in asth...
Background: Asthma is an airway inflammatory disease with functional and structural changes, leading...
Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recen...
Asthma is a chronic respiratory disease causing inflammation and remodeling of the lungs and airways...
The mechanism for the contribution of eosinophils (EOS) to asthma pathophysiology is not fully under...
Introduction Airway remodelling describes the histopathological changes in tissue architecture ob...
AbstractBackgroundAsthma is an airway inflammatory disease with functional and structural changes, l...
BACKGROUND AND OBJECTIVES: Airway remodeling is a main feature of asthma. Different biological pheno...
AbstractThe matrix metalloproteinase (MMP) enzymes MMP-9, have relevance to chronic structural airwa...
BACKGROUND: Recent studies have suggested that eosinophils may have a direct effect on airway smooth...
Airway remodeling is a hallmark feature of asthma, and one of its key structural changes is increase...
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lu...
Background: Airway smooth muscle (ASM) remodeling is an important component of the structural change...
Background: Eosinophils play an important role in the pathophysiology of asthma being implicated in ...
Background Eosinophils play an important role in the pathophysiology of asthma being implicated in a...
BackgroundEosinophilia is a marker of corticosteroid responsiveness and risk of exacerbation in asth...
Background: Asthma is an airway inflammatory disease with functional and structural changes, leading...
Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recen...
Asthma is a chronic respiratory disease causing inflammation and remodeling of the lungs and airways...
The mechanism for the contribution of eosinophils (EOS) to asthma pathophysiology is not fully under...
Introduction Airway remodelling describes the histopathological changes in tissue architecture ob...
AbstractBackgroundAsthma is an airway inflammatory disease with functional and structural changes, l...
BACKGROUND AND OBJECTIVES: Airway remodeling is a main feature of asthma. Different biological pheno...
AbstractThe matrix metalloproteinase (MMP) enzymes MMP-9, have relevance to chronic structural airwa...
BACKGROUND: Recent studies have suggested that eosinophils may have a direct effect on airway smooth...
Airway remodeling is a hallmark feature of asthma, and one of its key structural changes is increase...
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lu...
Background: Airway smooth muscle (ASM) remodeling is an important component of the structural change...