The asymmetric aza-silyl-Prins reaction: synthesis of enantiopure piperidines
- Mittapalli, Ramana R.
- Guesné, Sebastien J.J.
- Parker, Robert J.
- Klooster, Wim
- Coles, Simon J.
- Skidmore, John
- Dobbs, Adrian P.
DOI Publisher
American Chemical Society (ACS)Abstract
The design and development of the first asymmetric aza-silyl-Prins reaction is reported, giving rise to valuable and diverse piperidines and pipecolic acid derivatives in both high yields and as single enantiomers. The creation of a novel chiral auxiliary-homoallylic amine for the aza-silylPrins reaction is essential to its success
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