Loss of photoreceptor cells due to retinal degeneration is one of the main causes of blindness in the developed world. Although there is currently no effective treatment, cell replacement therapy using stem-cell-derived photoreceptor cells may be a feasible future treatment option. In order to ensure safety and efficacy of this approach, robust cell isolation and purification protocols must be developed. To this end, we previously developed a biomarker panel for the isolation of mouse photoreceptor precursors from the developing mouse retina and mouse embryonic stem cell cultures. In the current study we applied this approach to the human pluripotent stem cell (hPSC) system, and identified novel biomarker combinations that can be leveraged ...
Stem cell transplantation is widely considered as a promising therapeutic approach for photoreceptor...
Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retina...
Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy. We previous...
Loss of photoreceptors due to retinal degeneration is a major cause of untreatable blindness. Cell r...
BackgroundInherited and acquired retinal degenerations are frequent causes of visual impairment and ...
Inherited and acquired retinal degenerations are frequent causes of visual impairment and photorecep...
This study identifies and characterizes retinal stem cells (RSCs) in early postnatal to seventh-deca...
Retinal degenerative diseases are a major cause of untreatable blindness. Stem cell therapy to repla...
Inherited retinal dystrophies resulting in the death of the light sensitive photoreceptor cells are ...
The goal of the present study was threefold: to determine whether viable human retinal progenitor ce...
Summary: Photoreceptor degenerative diseases are a major cause of blindness for which cell replaceme...
The adult human retina has a population of Müller glia that exhibit stem cell characteristics. The ...
Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retina...
Retinal degeneration leads to loss of light-sensing photoreceptors eventually resulting in vision im...
Retinal degeneration often results in the loss of light-sensing photoreceptors, which leads to perma...
Stem cell transplantation is widely considered as a promising therapeutic approach for photoreceptor...
Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retina...
Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy. We previous...
Loss of photoreceptors due to retinal degeneration is a major cause of untreatable blindness. Cell r...
BackgroundInherited and acquired retinal degenerations are frequent causes of visual impairment and ...
Inherited and acquired retinal degenerations are frequent causes of visual impairment and photorecep...
This study identifies and characterizes retinal stem cells (RSCs) in early postnatal to seventh-deca...
Retinal degenerative diseases are a major cause of untreatable blindness. Stem cell therapy to repla...
Inherited retinal dystrophies resulting in the death of the light sensitive photoreceptor cells are ...
The goal of the present study was threefold: to determine whether viable human retinal progenitor ce...
Summary: Photoreceptor degenerative diseases are a major cause of blindness for which cell replaceme...
The adult human retina has a population of Müller glia that exhibit stem cell characteristics. The ...
Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retina...
Retinal degeneration leads to loss of light-sensing photoreceptors eventually resulting in vision im...
Retinal degeneration often results in the loss of light-sensing photoreceptors, which leads to perma...
Stem cell transplantation is widely considered as a promising therapeutic approach for photoreceptor...
Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retina...
Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy. We previous...