Murine experimental allergic encephalomyelitis (EAE) is a useful model for the demyelinating, autoimmune disease multiple sclerosis. In the EAE system, the immunodominant N-terminal epitope of myelin basic protein (MBP) is an unusually short, weakly binding peptide antigen which elicits highly biased TCR chain usage. In the 2.2 Å crystal structure of I-Au/MBP1-11 complex, only MBP residues 1-7 are bound toward one end of the peptide binding cleft. The fourth residue of MBP1-11 is located in an incompatible p6 pocket of I-Au, thus explaining the short half-life of I-Au complexed with Ac1-11. MBP peptides extended at the C terminus of Ac1-11 result in dramatic affinity increases, likely attributed to register shifting to a higher affinity cry...
Myelin basic protein (MBP) is a candidate autoantigen in multiple sclerosis (MS). Its dominant antig...
AbstractExperimental allergic encephalomyelitis (EAE) is induced by T cell–mediated immunity to cent...
Conformational epitopes of myelin oligodendrocyte glycoprotein (MOG) provide a major target for demy...
AbstractMurine experimental allergic encephalomyelitis (EAE) is a useful model for the demyelinating...
Experimental autoimmune encephalomyelitis can be induced in susceptible animals by immunodominant de...
This work reports molecular dynamics studies at the receptor level of the immunodominant myelin basi...
Thesis (Ph. D.)--University of Washington, 2003Experimental autoimmune encephalomyelitis (EAE) can b...
The involvement of Myelin Basic Protein (MBP) in Multiple Sclerosis (MS) has been widely discussed i...
Although myelin basic protein (MBP)-recognizing T cells are not readily obtained after immunization ...
Objective: Studies evaluating T-cell recognition of myelin oligodendrocyte glycoprotein (MOG) in mul...
AbstractStructural similarity between viral T cell epitopes and self-peptides could lead to the indu...
Autoantibodies targeting conformationally intact myelin oligodendrocyte glycoprotein (MOG) are found...
Autoantibodies targeting conformationally intact myelin oligodendrocyte glycoprotein (MOG) are found...
Mutations of peptides to generate altered peptide ligands, capable of switching immune responses fro...
Autoantibodies targeting conformationally intact myelin oligodendrocyte glycoprotein (MOG) are found...
Myelin basic protein (MBP) is a candidate autoantigen in multiple sclerosis (MS). Its dominant antig...
AbstractExperimental allergic encephalomyelitis (EAE) is induced by T cell–mediated immunity to cent...
Conformational epitopes of myelin oligodendrocyte glycoprotein (MOG) provide a major target for demy...
AbstractMurine experimental allergic encephalomyelitis (EAE) is a useful model for the demyelinating...
Experimental autoimmune encephalomyelitis can be induced in susceptible animals by immunodominant de...
This work reports molecular dynamics studies at the receptor level of the immunodominant myelin basi...
Thesis (Ph. D.)--University of Washington, 2003Experimental autoimmune encephalomyelitis (EAE) can b...
The involvement of Myelin Basic Protein (MBP) in Multiple Sclerosis (MS) has been widely discussed i...
Although myelin basic protein (MBP)-recognizing T cells are not readily obtained after immunization ...
Objective: Studies evaluating T-cell recognition of myelin oligodendrocyte glycoprotein (MOG) in mul...
AbstractStructural similarity between viral T cell epitopes and self-peptides could lead to the indu...
Autoantibodies targeting conformationally intact myelin oligodendrocyte glycoprotein (MOG) are found...
Autoantibodies targeting conformationally intact myelin oligodendrocyte glycoprotein (MOG) are found...
Mutations of peptides to generate altered peptide ligands, capable of switching immune responses fro...
Autoantibodies targeting conformationally intact myelin oligodendrocyte glycoprotein (MOG) are found...
Myelin basic protein (MBP) is a candidate autoantigen in multiple sclerosis (MS). Its dominant antig...
AbstractExperimental allergic encephalomyelitis (EAE) is induced by T cell–mediated immunity to cent...
Conformational epitopes of myelin oligodendrocyte glycoprotein (MOG) provide a major target for demy...