Possible new immunosuppressants through biosynthesis: Derivatives of the immunosuppressant rapamycin, such as analogue 3, are obtained by feeding simple carboxylic acids to the rapamycin‐producing organism. Incorporation of these alternative starter units appears to be preceded by their specific hydroxylation
Rapamycin is a small molecule originally isolated from nature. It has antibiotic and immunosuppressi...
From the original medicinal plants to the modern formulation laboratories, natural products have pla...
This dissertation describes synthetic studies culminating in the total synthesis of the macrocyclic ...
We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules govern...
Rapamycin is a drug with several important clinical uses. Its complex structure means that total syn...
peer reviewedThe macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prev...
The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell pr...
The macrolide rapamycin ( 1 ) was first described as an antifungal agent in 1975. Even though its bi...
This dissertation describes a stereoselective synthesis of two major fragments of rapamycin. Isolate...
A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo ...
Certain embodiments include carbonate esters of rapamycin at position 42 that are synthesized by a l...
A strategy for a total synthesis of the immunosuppressant agent rapamycin 1 is outlined and the ster...
Pacidamycins, mureidomycins and napsamycins are structurally related uridyl peptide antibiotics that...
For over 30 years, rapamycin has generated a sustained and intense interest from the scientific comm...
The appearance of new infectious diseases, the increase in multidrug-resistant bacteria, and the nee...
Rapamycin is a small molecule originally isolated from nature. It has antibiotic and immunosuppressi...
From the original medicinal plants to the modern formulation laboratories, natural products have pla...
This dissertation describes synthetic studies culminating in the total synthesis of the macrocyclic ...
We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules govern...
Rapamycin is a drug with several important clinical uses. Its complex structure means that total syn...
peer reviewedThe macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prev...
The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell pr...
The macrolide rapamycin ( 1 ) was first described as an antifungal agent in 1975. Even though its bi...
This dissertation describes a stereoselective synthesis of two major fragments of rapamycin. Isolate...
A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo ...
Certain embodiments include carbonate esters of rapamycin at position 42 that are synthesized by a l...
A strategy for a total synthesis of the immunosuppressant agent rapamycin 1 is outlined and the ster...
Pacidamycins, mureidomycins and napsamycins are structurally related uridyl peptide antibiotics that...
For over 30 years, rapamycin has generated a sustained and intense interest from the scientific comm...
The appearance of new infectious diseases, the increase in multidrug-resistant bacteria, and the nee...
Rapamycin is a small molecule originally isolated from nature. It has antibiotic and immunosuppressi...
From the original medicinal plants to the modern formulation laboratories, natural products have pla...
This dissertation describes synthetic studies culminating in the total synthesis of the macrocyclic ...
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