Concentrations of direct oral anticoagulants according to guidelines for the periprocedural management of low bleeding risk procedures.

Annually 1 in 10 patients treated with direct oral anticoagulant (DOAC) requires a planned invasive procedure. Most of these procedures are associated with a low bleeding risk. In this setting, guidelines recommend not to perform the procedure at DOAC peak concentration ([DOAC]), which occurs 1 to 3 hours after intake. [...