Biomarkers to diagnose ventricular dysfunction in childhood cancer survivors: a systematic review
- Leerink, J.M.
- Verkleij, S.J.
- Feijen, E.A.M.
- Mavinkurve-Groothuis, A.M.C.
- Pourier, M.S.
- Ylanen, K.
- Tissing, W.J.
- Louwerens, M.
- Heuvel, M.M. Van den
- Broeder, E. van Dulmen-den
- Vries, A.C.M. de
- Ronckers, C.M.
- Pal, H.J. van der
- Kapusta, L.
- Loonen, J.J.
- Bellersen, L.
- Pinto, Y.M.
- Kremer, L.C.
- Kok, W.E.
DOIAbstract
OBJECTIVE: To systematically review the literature and assess the diagnostic value of biomarkers in detection of late-onset left ventricular (LV) dysfunction in childhood cancer survivors (CCS) treated with anthracyclines. METHODS: We systematically searched the literature for studies that evaluated the use of biomarkers for detection of LV dysfunction in CCS treated with anthracyclines more than 1 year since childhood cancer diagnosis. LV dysfunction definitions were accepted as an ejection fraction <50% or <55% and/or a fractional shortening <28%, <29% or <30%. Contingency tables were created to assess diagnostic accuracies of biomarkers for diagnosing LV dysfunction. RESULTS: Of 1362 original studies screened, eight heterogeneous studies...
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