Analysis of diazepam (DZP) and its active metabolite nordiazepam (NDZP) in plasma is commonly performed in clinical medicine to ensure proper therapeutic effects while minimizing the incidence of toxicity. This study aimed to optimize analytical parameters and compare two pre-treatment techniques, liquid-liquid (LLE) and solid phase extraction (SPE), as well as liquid chromatographic conditions to analyze simultaneously DZP and NDZP in plasma from 20 patients treated with a daily dose of 10 mg. Both techniques showed to be well in line with the international criteria for analytical validation, which permitted to quantify DZP (66.2 - 1148.6 ng mL-1) and NDZP (138.5 - 808.6 ng mL -1) in all samples. The correlation coefficients between SPE an...
A simple and high-throughput method to simultaneously determine selected benzodiazepines (i.e., diaz...
A rapid, sensitive and specific method for quantifying clonazepam in human plasma using diazepam as ...
The work is about benzodiazepine mixture consisting of diazepam, alprazolam and dipotassium clorazep...
A method for simultaneous determination of seven benzodiazepines (BZPs) (flunitrazepam, clonazepam, ...
Background/Aim. Diazepam is a benzodiazepine anxyolitic. Metabolism of diazepam takes place in liver...
Drug analysis is an imperative activity to check the quality of a drug compound. Pharmacopoeial mono...
Accurate methods are described for the qualitative and quantitative determination of medazepam, di-a...
The aim is to carry out the quantitative evaluation of the active substances of diazepam and clonaze...
Benzodiazepines are among the most prescribed drugs for the treatment of a wide spectrum of clinical...
A simple and rapid procedure for the simultaneous screening of 14 benzodiazepines in oral fluid is p...
In this study, a special interest was focused on the stability of diazepam and nordiazepam in aqueou...
Diazepam is frequently used as an adjuvant during antidepressant therapy. Recently, some studies hav...
none5Diazepam (7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one) is one of the most...
A simple, rapid method for the determination of the benzodiazepines, diazepam and chlordiazepoxide, ...
Aim: To determinate the most commonly used benzodiazepine derivatives in Lithuania: diazepam, medaze...
A simple and high-throughput method to simultaneously determine selected benzodiazepines (i.e., diaz...
A rapid, sensitive and specific method for quantifying clonazepam in human plasma using diazepam as ...
The work is about benzodiazepine mixture consisting of diazepam, alprazolam and dipotassium clorazep...
A method for simultaneous determination of seven benzodiazepines (BZPs) (flunitrazepam, clonazepam, ...
Background/Aim. Diazepam is a benzodiazepine anxyolitic. Metabolism of diazepam takes place in liver...
Drug analysis is an imperative activity to check the quality of a drug compound. Pharmacopoeial mono...
Accurate methods are described for the qualitative and quantitative determination of medazepam, di-a...
The aim is to carry out the quantitative evaluation of the active substances of diazepam and clonaze...
Benzodiazepines are among the most prescribed drugs for the treatment of a wide spectrum of clinical...
A simple and rapid procedure for the simultaneous screening of 14 benzodiazepines in oral fluid is p...
In this study, a special interest was focused on the stability of diazepam and nordiazepam in aqueou...
Diazepam is frequently used as an adjuvant during antidepressant therapy. Recently, some studies hav...
none5Diazepam (7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one) is one of the most...
A simple, rapid method for the determination of the benzodiazepines, diazepam and chlordiazepoxide, ...
Aim: To determinate the most commonly used benzodiazepine derivatives in Lithuania: diazepam, medaze...
A simple and high-throughput method to simultaneously determine selected benzodiazepines (i.e., diaz...
A rapid, sensitive and specific method for quantifying clonazepam in human plasma using diazepam as ...
The work is about benzodiazepine mixture consisting of diazepam, alprazolam and dipotassium clorazep...