Regiospecific synthesis of new non-condensed heteropolycyclic systems from beta-heteroaryl-beta-methoxyvinyl trihalomethyl ketones

A novel series of twelve heteroaroyl-2-pyrazolines trihalomethyl and substituted heteroaryl, as non-condensed heteropolycyclic systems, have been synthesized in one-step in 50-78% yield from the regiospecific cyclocondensation reaction of 1,1,1-trifluoro(chloro)-4-methoxy-4-(2-furyl)- and 4-(2-thienyl)-3-buten-2-ones (beta-alkoxyvinyl trihalometil ketones) with furoic hydrazide, 2-thiophenecarboxylic hydrazide and isonicotinic acid hydrazide (heteroaroylhydrazines) under mild conditions in methanol as solvent.Reações de ciclo-condensação envolvendo 1,1,1-trifluor(cloro)-4-metoxi-4-(2-heteroaril)-3-buten-2-onas (beta-alcoxivinil trialometil cetonas) e furoil-, tenoil- e isonicotinoil-hidrazinas (heteroarilhidrazidas), realizadas sob condições brandas e em meio alcoólico, forneceram em passo reacional único e regioespecificamente, uma série inédita composta por doze heteroaroil-2-pirazolinas trialometil heteroaril substituídas em rendimentos de 50-78%; um novo sistema heteropolicíclico não condensado