Beta-2-agonists have been widely used by asthmatic subjects to relieve their obstructive symptoms. However, there are reports that continuous use could lead to loss of bronchial protection and exacerbation of asthma symptoms. We evaluated the effect of two regimens of salbutamol administration (twice and five times a week) in a model of chronic airway inflammation in male Hartley guinea pigs (protocol starting weight: 286 ± 30 g) induced by repeated exposures to aerosols of ovalbumin (OVA). After sensitization, guinea pigs were exposed to aerosols of 0.1 mg/ml salbutamol solution twice a week (OVA + S2x, N = 7) or five times a week (OVA + S5x, N = 8). We studied allergen-specific (OVA inhalation time) and -nonspecific (response to methachol...
This study describes a model of allergen-induced early and late responses in non-anaesthetised guine...
The present study was undertaken to determine the effect of furosemide on antigen-induced bronchocon...
Oral tolerance attenuates changes in in vitro lung tissue mechanics and extracellular matrix remodel...
Effect of salbutamol on pulmonary responsiveness in chronic pulmonary allergic inflammation in guine...
Efficacy Of beta(2)-agonists (B2), anticholinergics, corticosteroids, anti-inflammatory drugs or ant...
Salbutamol consists of a racemic mixture of R- and S-salbutamol. R-salbutamol (levalbuterol) is the ...
We tested the hypothesis that regular inhaled ß₂ adrenergic receptor (ß₂AR) agonist administration ...
Background and Purpose Asthma exacerbations contribute to corticosteroid insensitivity. Lipopolysacc...
Asthma is a serious health problem that affects over 2.4 million Canadians. Asthma and allergy are ...
Previous studies have shown that guinea pigs which have been sensitized to ovalbumin (OA) become unr...
We investigated the effects of oral tolerance (OT) in controlling inflammatory response, hyperrespon...
In a new model using conscious, unrestrained and ovalbumin-sensitized guinea pigs, we investigated t...
Copyright © 2014 Zahra Gholamnezhad et al. This is an open access article distributed under the Crea...
Background: We have previously shown that lipopolysaccharide (LIPS) exposure in sensitised animals 1...
The pharmacological actions of the new xanthine, isbufylline, were evaluated in several models of ai...
This study describes a model of allergen-induced early and late responses in non-anaesthetised guine...
The present study was undertaken to determine the effect of furosemide on antigen-induced bronchocon...
Oral tolerance attenuates changes in in vitro lung tissue mechanics and extracellular matrix remodel...
Effect of salbutamol on pulmonary responsiveness in chronic pulmonary allergic inflammation in guine...
Efficacy Of beta(2)-agonists (B2), anticholinergics, corticosteroids, anti-inflammatory drugs or ant...
Salbutamol consists of a racemic mixture of R- and S-salbutamol. R-salbutamol (levalbuterol) is the ...
We tested the hypothesis that regular inhaled ß₂ adrenergic receptor (ß₂AR) agonist administration ...
Background and Purpose Asthma exacerbations contribute to corticosteroid insensitivity. Lipopolysacc...
Asthma is a serious health problem that affects over 2.4 million Canadians. Asthma and allergy are ...
Previous studies have shown that guinea pigs which have been sensitized to ovalbumin (OA) become unr...
We investigated the effects of oral tolerance (OT) in controlling inflammatory response, hyperrespon...
In a new model using conscious, unrestrained and ovalbumin-sensitized guinea pigs, we investigated t...
Copyright © 2014 Zahra Gholamnezhad et al. This is an open access article distributed under the Crea...
Background: We have previously shown that lipopolysaccharide (LIPS) exposure in sensitised animals 1...
The pharmacological actions of the new xanthine, isbufylline, were evaluated in several models of ai...
This study describes a model of allergen-induced early and late responses in non-anaesthetised guine...
The present study was undertaken to determine the effect of furosemide on antigen-induced bronchocon...
Oral tolerance attenuates changes in in vitro lung tissue mechanics and extracellular matrix remodel...