Add to ORKGWe applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH), to characterize the genetic aberrations in three osteosarcomas (OS) and one Ewing's sarcoma. CGH identified recurrent chromosomal losses at 10p14-pter and gains at 8q22.3-24.1 in OS. Interphase FISH allowed to confirm 8q gain in two cases. A high amplification level of 11q12-qter was detected in one OS. The Ewing's sarcoma showed gain at 1p32-36.1 as the sole chromosome alteration. These studies demonstrate the value of molecular cytogenetic methods in the characterization of recurrent genomic alterations in bone tumor tissue
Most osteosarcomas are highly aggressive malignancies characterized by a complex pattern of chromoso...
The chromosomal organization of amplified chromosome 12 sequences was studied with fluorescence in s...
Specific and consistent genetic rearrangements have been found to be associated with particular tumo...
We applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridi...
Osteosarcomas (OS) are aggressive tumors of the bone and often have a poor prognosis, Conventional c...
Fibrosarcoma of bone is a rare malignant tumor accounting for less than 5% of all primary malignant ...
O osteossarcoma (OS) é o tumor ósseo maligno mais freqüente da infância e adolescência com uma taxa...
O osteossarcoma (OS) é o tumor ósseo maligno mais freqüente da infância e adolescência com uma taxa...
Soft tissue sarcomas are a heterogeneous group of malignant tumors displaying a wide range of clinic...
Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in children and ad...
The detection of structural and numerical chromosomal aberrations is an important part of the charac...
The detection of structural and numerical chromosomal aberrations is an important part of the charac...
Background. The majority of karyotypes observed in osteosarcomas (OS) and chondrosarcomas (CS) are c...
Background. The majority of karyotypes observed in osteosarcomas (OS) and chondrosarcomas (CS) are c...
Among the small round cell tumors differential diagnosis is particularly difficult for their undiffe...
Most osteosarcomas are highly aggressive malignancies characterized by a complex pattern of chromoso...
The chromosomal organization of amplified chromosome 12 sequences was studied with fluorescence in s...
Specific and consistent genetic rearrangements have been found to be associated with particular tumo...
We applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridi...
Osteosarcomas (OS) are aggressive tumors of the bone and often have a poor prognosis, Conventional c...
Fibrosarcoma of bone is a rare malignant tumor accounting for less than 5% of all primary malignant ...
O osteossarcoma (OS) é o tumor ósseo maligno mais freqüente da infância e adolescência com uma taxa...
O osteossarcoma (OS) é o tumor ósseo maligno mais freqüente da infância e adolescência com uma taxa...
Soft tissue sarcomas are a heterogeneous group of malignant tumors displaying a wide range of clinic...
Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in children and ad...
The detection of structural and numerical chromosomal aberrations is an important part of the charac...
The detection of structural and numerical chromosomal aberrations is an important part of the charac...
Background. The majority of karyotypes observed in osteosarcomas (OS) and chondrosarcomas (CS) are c...
Background. The majority of karyotypes observed in osteosarcomas (OS) and chondrosarcomas (CS) are c...
Among the small round cell tumors differential diagnosis is particularly difficult for their undiffe...
Most osteosarcomas are highly aggressive malignancies characterized by a complex pattern of chromoso...
The chromosomal organization of amplified chromosome 12 sequences was studied with fluorescence in s...
Specific and consistent genetic rearrangements have been found to be associated with particular tumo...