Add to ORKGEstradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.40...
Nodules formation in goiter is still poorly understood due to the lack of an adequate animal model. ...
Abstract Background Estrogen therapy is widely used nowadays in women to treat many postmenopausal s...
The acute effects of increasing doses of sodium iodide were studied on human thyroid follicles isola...
Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid fo...
Iodide uptake by the sodium/iodide symporter (NIS) in thyrocytes is essential for thyroid hormone pr...
The inhibitory effect of supraphysiological iodide concentrations on thyroid hormone synthesis (Wolf...
AbstractThe inhibitory effect of supraphysiological iodide concentrations on thyroid hormone synthes...
Background: Various clinical and experimental findings support the concept that human chorionic gona...
Abstract We have explored the mechanisms whereby iodine inhibits thyroid growth using as models bot...
Thyroid autonomy is a frequent cause of thyrotoxicosis in regions with iodine deficiency. Epidemiolo...
The factors mediating the accumulation of thyroglobulin are of great importance to the understanding...
BACKGROUND: Thyroid gland is highly dependent on dietary intake of iodine for normal function, so...
The effects of exogenous 17B-estradiol and progesterone on thyroidal activity in the ovariectomized ...
We have explored the mechanisms whereby iodine inhibits thyroid growth using as models both the FRTL...
In the first part of this work, we give a general review of the literature. Chapter 1 comprises a d...
Nodules formation in goiter is still poorly understood due to the lack of an adequate animal model. ...
Abstract Background Estrogen therapy is widely used nowadays in women to treat many postmenopausal s...
The acute effects of increasing doses of sodium iodide were studied on human thyroid follicles isola...
Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid fo...
Iodide uptake by the sodium/iodide symporter (NIS) in thyrocytes is essential for thyroid hormone pr...
The inhibitory effect of supraphysiological iodide concentrations on thyroid hormone synthesis (Wolf...
AbstractThe inhibitory effect of supraphysiological iodide concentrations on thyroid hormone synthes...
Background: Various clinical and experimental findings support the concept that human chorionic gona...
Abstract We have explored the mechanisms whereby iodine inhibits thyroid growth using as models bot...
Thyroid autonomy is a frequent cause of thyrotoxicosis in regions with iodine deficiency. Epidemiolo...
The factors mediating the accumulation of thyroglobulin are of great importance to the understanding...
BACKGROUND: Thyroid gland is highly dependent on dietary intake of iodine for normal function, so...
The effects of exogenous 17B-estradiol and progesterone on thyroidal activity in the ovariectomized ...
We have explored the mechanisms whereby iodine inhibits thyroid growth using as models both the FRTL...
In the first part of this work, we give a general review of the literature. Chapter 1 comprises a d...
Nodules formation in goiter is still poorly understood due to the lack of an adequate animal model. ...
Abstract Background Estrogen therapy is widely used nowadays in women to treat many postmenopausal s...
The acute effects of increasing doses of sodium iodide were studied on human thyroid follicles isola...