Modulacija mikrobioma kože

Koža je fizička barijera, ali ujedno posjeduje kemijski i imunološke definirane obrambene sposobnosti. Na njoj se također nalaze i mikrobiote. Izuzev dobro proučavanih mikrobnih zajednica, kao što su gastrointestinalni sustav i rodnica, mikrobiom kože također je zanimljiv za znanstvena istraživanja. U ovome radu diskutirat će se o mikrobiomu kože, rasprostranjenosti mikrobiota na koži (bakterija, arheja i eukariotskih stanica) i o njihovoj ulozi u eubiozi. Diskusija će se posebice fokusirati na mikrobiotama pazušne jame i njihovoj ulozi tvorbe (neugodnog) mirisa tijela u cilju smanjenja tog mirisa. S druge strane, objasnit će se primjena antiseptika (kao biocida) na koži ruku u cilju smanjenja mikrobne populacije (stalne ili povremene), kao i velike uloge pranja ruku u javnom zdravstvu.The skin as an organ is a physical barrier but it also has chemically and immunologically defined defensive properties. Skin also harbors microbiota. Besides the widely studied microbial communities such as the gastro-intestinal tract and the vaginal epithelia, the skin microbiome is also an interesting target of scientific research. In this thesis we shall discuss skin microbiome properties, the diversity of microbiota on the skin (bacteria, archaea and eukaryotic cells) and their role in eubiosis. The discussion will be especially focused on explaining the diversity of microbiota in the armpit (axillae) and their role in the occurrence of unpleasant body odor with the goal of reducing that odor. The next focus of the present thesis will be on the use of antiseptics (as biocides) on the skin of the hands with the goal of reducing the microbial population (resident or transient) as well as the major role of washing hands in public health. Taking into account resident and transient microbiota on the skin of the hands, the use of antiseptics has a major impact on the spreading of multiple-resistant microbial species via hands, which is an important public health issue