Biofilm as virulance factor of Acinetobacter baumannii

Biofilm je sve aktualnija tema i sve više se istražuje, a veće razumijevanje biofilma trebalo bi dovesti do novih, učinkovitijih strategija kontrole i poboljšanja liječenja pacijenata. Trend porasta rezistentnosti biofilma na antibiotike postaje sve ozbiljniji problem, a rješenje se pokušava pronaći kombinacijom različitih mjera poput izbjegavanja infekcija, blokiranja bakterijskih čimbenika virulencije ili pojačavanja imunološke obrane domaćina, potiskujući bakterije u biofilmu na prethodnu ulogu kao fakultativne ili rijetko patogene bakterije. Cilj rada je bio opisati najznačajnija svojstva biofilma: od procesa njegovog nastajanja, preko rasprostiranja u okoliš, kao uzročnika virulencije kod bakterija te rezistentnosti na antibiotike. Težište rada bilo je na biofilmovima koji su nastali djelovanjem bakterije Acinetobacter baumannii.Biofilm is an important topic and there is more and more research in this area. A better understanding of biofilm should lead to new, more effective strategies for controlling and improving treatment of patients. The increasing trend of a biofilm resistance to antibiotic treatment become more and more serious problem, and the solution is to find a combination of different measures such as avoiding infections, blocking the factors of a bacterial virulence, or the host immunity increasing by suppressing bacterial cells in biofilm to reduce their pathogenicity. The aim of the paper was to describe the most important biofilm properties: from the process of its formation, through migration to the environment, as a bacterial virulence agent and and biofilm antibiotic resistance. The focus of the theses was on biofilms produced by the Acinetobacter baumannii