N-terminal modification of glycine with an enediyne supstituent

Endiinski antitumorski antibiotici već 30 godina bude interes kemičara zbog sposobnosti ciklizacije u vrlo reaktivan 1,4-didehidrobenzenski biradikal, koji posjeduje sposobnost cijepanja dvostruke uzvojnice DNA. U svrhu dobivanja jednostavnijih analoga endiina, u okviru ovog diplomskog rada priređeni su i karakterizirani derivati glicina modificirani na amino-kraju propargilnim, kloroeninskim i hidroksiendiinskim supstituentima.Enediyne anticancer antibiotics have intrigued chemists for over 30 years because of their abilliy to cyclize to a highly reactive 1,4-didehydrobenzenoid diradical, highly reactive structure capable of the DNA double helix breakage. As a part of the ongoing studies on the synthesis of enediyne analogs, within the framework of this graduated thesis glycine derivates carrying propargyl, chloroenyne and hydroxyenediyne substituents at the N-terminus, have been prepared