Risk factors association with skin malignomas in kidney transplanted patients in University Hospital Osijek

Cilj. Utvrditi prevalenciju kožnih malignoma (KM) u bolesnika s bubrežnim presatkom koji se kontroliraju u KBC-u Osijek i ispitati jesu li dob, duljina i vrsta imunosupresivnog (IS) liječenja udruženi s njihovom pojavom. Nacrt istraživanja. Presječno istraživanje. Ispitanici i postupci. Podaci za 171 bolesnika s bubrežnim presatkom, od toga 53,2 % muškaraca, medijana dobi 56 godina, preuzeti su iz medicinskih zapisa i statistički obrađeni pomoću SPSS-a. Rezultati. 7 % bolesnika liječeno je zbog KM-a nakon TX-a: bazocelularni karcinom u 6, planocelularni karcinom u 2, Kaposijev sarkom u 2, displazija u jednoga i nepoznate histologije u jednog bolesnika. Između oboljelih od KM-a i ostalih nije bilo značajne razlike s obzirom na spol, dob pri prvoj dijalizi, dob pri posljednjem TX-u, trajanju dijalize prije TX-a, godinama nakon posljednjeg TX-a, osnovnoj bubrežnoj bolesti ni kreatininemiji. Bolesnici s KM bili su značajno stariji od ostalih. Oboljeli od KM-a nisu imali zanimanja povezana s povećanom izloženosti suncu. Bolesnici s KM rjeđe su liječeni kalcineurinskim inhibitorima i antiproliferacijskim lijekovima, češće mTOR inhibitorima, a podjednako kortikosteroidima. Samo 52,1 % njih bilo je ikad dermatološki pregledano, 31,6 % nakon TX-a, a samo 4 ispitanika preventivno. Zaključak. Starija dob značajno je udružena s pojavom KM-a u transplantiranih bubrežnih bolesnika. Oboljeli od KM-a nisu dulje liječeni imunosupresivima i imali su prikladnu imunosupresiju. Ispitanici nisu sustavno dermatološki pregledavani.Aim. To examine skin malignancy prevalence in kidney transplanted patients with regular check-ups in CHC Osijek and to determine their association with age, duration of IS therapy and IS drugs’ kinds. Research draft. The research was of cross-sectional type. Subjects and methods 171 kidney transplanted patients were included, 53.2 % males, median age 56 years. The data were taken from medical records and statistically analyzed with SPSS program. Results. Skin malignancy after kidney TX was found in 7 % of the patients: 6 patients had basalioma, 2 squamous cell carcinoma, 2 had Kaposi sarcoma, 1 skin dysplasia and 1 had skin malignancy of unknown histology. Patients with skin malignancies did not differ from those without that disease in gender, age at first dialysis, dialysis duration, age at last TX or the time after the last TX. They were significantly older. Their professions were not associated with greater sun exposure. They were treated with CNIs and antiprolipherative drugs less often and with mTOR inhibitors more frequently, while the frequency of steroid treatment was not different. IS regimens distribution differed significantly between patients with skin malignancies and without them. Only 51.2 % of patients had skin examination ever and 31.6 after TX. Only 4 patients underwent preventive skin examination. Conclusion. Older age was associated with skin malignancies in kidney transplanted patients. Those with skin malignancies were not treated longer time with immunosuppression and had appropriately adjusted immunosuppression. Kidney transplanted patients were not skin examined per protocol