CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF INVASIVE CANDIDA INFECTIONS IN CHILDREN FROM 2011 TO 2015

CILJ ISTRAŽIVANJA: Cilj istraživanja bio je prikazati epidemiološke i kliničke karakteristike invazivne kandida infekcije, utvrditi vrste patogena i rizične čimbenike za razvoj infekcije. MATERIJALI I METODE: Retrospektivna analiza medicinske dokumentacije bolesnika hospitaliziranih u Klinici za dječje bolest KBC Split u razdoblju od 1. siječnja 2011. do 31. prosinca 2015. koji su tijekom hospitalizacije preboljeli invazivnu kandida infekciju. U istraživanje je uključeno 17 ispitanika. REZULTATI: Istraživanje je pokazalo da su invazivnu kandida infekciju podjednako često uzrokovali C. albicans i C. parapsilosis. Promatrajući povezanost spola s razvojem infekcije, došlo se do zaključka, da je infekcija Candidom, neovisno o vrsti, učestalija kod ženskog spola. Porastom dobi bolesnika smanjuje se incidencija infekcija uzrokovanih C. albicans, a raste incidencija infekcija s C. parapsilosis. Trajanje hospitalizacije do trenutka pozitivne hemokulture duže je kod infekcije uzrokovane C. parapsilosis. Ne postoji značajna razlika u čimbenicima rizika za nastanak infekcije s Candidom albicans i Candidom parapsilosis. Prosječne vrijednosti leukocita i CRP-a su veće kod infekcije uzrokovane C. albicans, ali razlike nisu dosegnule statističku značajnost. ZAKLJUČAK: Ne postoji značajna razlika u čimbenicima rizika za nastanak infekcije s Candidom albicans i Candidom parapsilosis. Rezultati utvrđeni ovim istraživanjem, bitnije ne odstupaju od rezultata utvrđenih istraživanjima u drugim bolničkim centrima.OBJECTIVE: The aim of this study was to show the epidemiological and clinical characteristics of invasive Candida infections, determine the type of pathogens and risk factors for infection. MATERIALS AND METHODS: A retrospective analysis of medical records of patients hospitalized in the Department of Pediatrics of the University Hospital Centre Split in the period from 2011 to 2015 who were diagnosed with invasive Candida infection. The study included 17 patients. RESULTS: The analysis has shown that invasive Candida infection was equally caused by Candida albicans and Candida parapsilosis. Regarding the association of gender with the development of infection, it was found that the Candida infection, regardless of the type, was more common in female patients. The incidence of infections caused by C. albicans decreases with age, while the incidence of C. parapsilosis increases. The duration of hospitalization until the moment of positive blood culture is longer when the infection is caused by C. parapsilosis. There was no significant difference in risk factors for infection with Candida albicans and Candida parapsilosis. Average values of leukocytes and CRP were higher in patients with infections caused by C. albicans, but the differences did not reach statistical significance. CONCLUSION: There was no significant difference in risk factors for infection with Candida albicans and Candida parapsilosis. Risk factors for Candida infections, defined in this study, do not differ significantly from the results of research established in other hospital