Growth inhibition in selected microorganisms by natural and synthetised compounds

U ovom radu određivano je antimikrobno djelovanje standardnih spojeva kumarina i 5-bromo-4-hidroksi-6-(p-tolil)-3-(p-toluil)-2H-piran-2-on (BrDHT, derivat dehidracetne kiseline) na odabrane sojeve bakterija, plijesni i kvasaca difuzijskom metodom, pri čemu su zone inhibicije rasta mjerene na čvrstim podlogama u Petrijevim zdjelicama. Dobiveni rezultati su pokazali da kumarin i BrDHT pokazuju antimikrobno djelovanje na svim istraživanim mikroorganizmima, iako se kod većine sojeva to djelovanje pojavilo samo pri većim količinama upotrebljenog inhibitora.The antimicrobial effect of standard compounds coumarin and 5-bromo-4- hydroxy-3-(p-toluoyl)-6-(p-tolyl)-2H-pyrane-2-one (BrDHT) as newly synthetized derivative of dehydroacetic acid were tested on selected bacteria, yeasts and moulds strains by disc-diffusion method. Inhibition zones were measured on solid medium in Petri dishes. The obtained results have shown that coumarin and BrDHT inhibit growth of all tested microorganisms, although this inhibitory effect occured only with a high amount of used inhibitor