Periodontal regeneration using collagen materials, dental stem cells and growth factors: a comparative study in minipigs

The aim of this study was to examine the regenerative potential of different collagen materials +/- a growth factor cocktail or +/- periodontal ligament stem cells comparatively in 60 class II furcation defects in swine. A significant increase in regeneration was observed in all groups. The new attachment formation reached a maximum of 77 %. The study shows that all implanted materials improved periodontal regeneration. However, neither the additional application of growth factors nor the stem cells lead to a further statistically significant increase in new attachment