PATHOGENS ISOLATED FROM BLOOD CULTURES AND THEIR SUSCEPTIBILITY IN ICU OF THE DEPARTMENT OF ANESTHESIOLOGY, REANIMATOLOGY AND INTENSIVE CARE, UHC SPLIT IN 2015

CILJ ISTRAŽIVANJA: Cilj rada je retrospektivnom analizom utvrditi najčešće izolate iz hemokulture i njihovu osjetljivost na pojedine antibiotike u Jedinici intenzivnog liječenja Klinike za anesteziologiju, reanimatologiju i intenzivno liječenje KBC Split u godini 2015. kako bi se na temelju najčešćih uzočnika i najuspješnijih antibiotika prethodne, u sljedećoj godini pacijentima ordinirala što uspješnija inicijalna terapija. MATERIJALI I METODE: Retrospektivnim, kohortnim istraživanjem obuhvaćeni su svi pacijenti liječeni u JIL-u KBC-a Split, njih 104 kojima su hemokulture bile pozitivne u 2015.godini. REZULTATI: Rezultati nisu pokazali očekivani veći udio gram negativnih u odnosu na gram pozitivne uzročnike, kao ni značajan broj gljiva kao uzročnika septičkih stanja. Razlika u postotku između gram negativnih i gram pozitivnih još uvijek je velika, ali prema svjetskim trendovima porasta možemo pretpostaviti da će se taj broj u budućnosti ipak povećati. Radilo se o 63,1% gram pozitivnih, 35,4% gram negativnih izolata i 1,3% gljiva. ZAKLJUČAK: Problemi s kojima se susreću JIL-ovi u drugim zemljama kao što su sve učestalije gram negativne sepse i nedjelotvornost antibiotika zbog rezistencije u JIL-u KBC-a Split nisu toliko izraženi. Gram pozitivni uzročnici prevladavaju, a i oni najtvrdokorniji pokazuju dobru osjetljivost na antibiotike. Ni značajan udio gljiva prema rezultatima nije zabilježen, što je svakako dobro zbog tvrdokornih infekcija koje uzrokuju, mortaliteta, i troškova liječenja.OBJECTIVE: The main aim of this research was to define most common isolates from hemo culture an their sensibility to different antibiotics, using the retrospective analysis in Unit of intensive care of the Department of anesthesiology, reanimatology and intensive care UHC Split in 2015. Based on facts regarding the most common causes and the most successful antibiotic treatment in last year, patients in next year would be able to get more successful initial therapy. MATERIALS AND METHODS: Retrospective, cohort research included all patients treated in ICU of UHC Split, 104 of them whose hemocultures were positive in 2015. RESULTS: Results didnt show expected higher percentage of gram negative infective agents comparing to gram positive. As well as percentage of fungi as infective agents was very low. The difference between gram negative and gram positive agents is rather high. But the expectation is that difference will decrease. So in the future gram negative agents will have higher percent. In this research there were 63,1% gram positive agents 35,4% gram negative agents and 1,3% of fungi. CONCLUSION: Problems facing ICUs in other countries are increased gram negative sepsis and inefficacy of antibiotics in ICU of UHC Split are not that much expressed. Gram positive agents prevail, and the most serious ones show sufficinet sensitivity to antibiotics. Increased percentage of fungi is also not recorded, which is good because of the severitry of infections, high mortality, and also increased cost of tretment