<p>To ensure human health, it is essential to characterize the genotoxic potential of new chemical entities such as pharmaceutical and cosmetic substances. In a first tier a battery of regulatory accepted in vitro tests is recommended. These tests have a relatively high sensitivity, but a low specificity. Furthermore, they are time-consuming, laborious and require large quantities of the individual chemicals. New assays overcoming these drawbacks are under development, the majority of them being reporter-based assays. In this paper we investigate the performance of two in vitro reporter-based assays, namely the Vitotox and the ToxTracker. A set of reference compounds were selected to cover not only different mechanisms of genotoxic ac...
Genetic toxicity testing is used as an early surrogate for carcinogenicity testing. Genetic toxicity...
Genotoxicity testing is an important component of toxicity assessment. As illustrated by the Europea...
AbstractThe Cosmetics Europe (formerly COLIPA) Genotoxicity Task Force has driven and funded three p...
Genetic toxicology is an essential component of compound safety assessment. In the face of a barrage...
AbstractFor the assessment of genotoxic effects of cosmetic ingredients, a number of well-establishe...
The assessment of genotoxicity represents an essential component of the safety assessment of all typ...
In drug development, toxicity is an important factor for attrition, resulting in a failure rate of 3...
The strategy for assessing human health risks of chemicals consists of a large number of tests in di...
Background In risk assessment, genotoxicity is a key factor to determine the safety for the consumer...
The strategy for assessing human health risks of chemicals consists of a large number of tests in di...
Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-genotoxic carcin...
The strategy for assessing human health risks of chemicals consists of a large number of tests in di...
Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical eval...
The minimal three-test battery of the International Conference on Harmonization guideline has been i...
Environmental and human health implications of endocrine disrupting chemicals (EDCs), particularly x...
Genetic toxicity testing is used as an early surrogate for carcinogenicity testing. Genetic toxicity...
Genotoxicity testing is an important component of toxicity assessment. As illustrated by the Europea...
AbstractThe Cosmetics Europe (formerly COLIPA) Genotoxicity Task Force has driven and funded three p...
Genetic toxicology is an essential component of compound safety assessment. In the face of a barrage...
AbstractFor the assessment of genotoxic effects of cosmetic ingredients, a number of well-establishe...
The assessment of genotoxicity represents an essential component of the safety assessment of all typ...
In drug development, toxicity is an important factor for attrition, resulting in a failure rate of 3...
The strategy for assessing human health risks of chemicals consists of a large number of tests in di...
Background In risk assessment, genotoxicity is a key factor to determine the safety for the consumer...
The strategy for assessing human health risks of chemicals consists of a large number of tests in di...
Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-genotoxic carcin...
The strategy for assessing human health risks of chemicals consists of a large number of tests in di...
Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical eval...
The minimal three-test battery of the International Conference on Harmonization guideline has been i...
Environmental and human health implications of endocrine disrupting chemicals (EDCs), particularly x...
Genetic toxicity testing is used as an early surrogate for carcinogenicity testing. Genetic toxicity...
Genotoxicity testing is an important component of toxicity assessment. As illustrated by the Europea...
AbstractThe Cosmetics Europe (formerly COLIPA) Genotoxicity Task Force has driven and funded three p...