The incidence of Celiac Disease at the Department of Pediatrics, University Hospital Centre Split in the time period from 2012 to 2016

Cilj: Glavni cilj istraživanja bio je utvrditi broj novodijagnosticirane djece oboljele od celijakije u Klinici za dječje bolesti KBC-a Split u razdoblju od 2012. do 2016. godine. Osim toga, istražena je i dob bolesnika u vrijeme postavljanja dijagnoze, raspodjela po spolu, kao i broj bolesnika po pojedinoj kategoriji Marsh – Oberhuber klasifikacije. Materijali i metode: U ovo retrospektivno istraživanje uključeno je 127 ispitanika s novodijagnosticiranom celijakijom. Uključeni su ispitanici oba spola, u dobi od 0-18 godina. Podaci o broju oboljele djece prikupljeni su pretraživanjem medicinske dokumentacije Klinike za dječje bolesti KBC-a Split. Svakom bolesniku analizirani su: dob, spol i stupanj bolesti po Marsh – Oberhuberovoj klasifikaciji. Rezultati su obrađeni deskriptivnim (standardnim) statističkim metodama i prikazani tablično i grafički. Rezultati: U Klinici za dječje bolesti KBC-a Split u razdoblju od 1. siječnja 2012. do 31. prosinca 2016. otkriveno je ukupno 127 novooboljele djece od celijakije. 71 (56%) je ženskog spola, a 56 (44%) muškog spola. Medijan dobi bolesnika bio je 132 mjeseca (raspon od 5 – 213), a prosječna dob 120.9 mjeseci. Podjelom prema dobnim skupinama, najviše djece pronađeno je u skupini iznad 10 godina, njih 73 (57.48%). U skupini 0-6 godina bilo je 32 (25.2%), a u skupini od 6-10 godina 22 (17.32%) djece. Izračunata incidencija za Splitsko – dalmatinsku županiju iznosi 1.24/1000, što predstavlja 124/100 000 djece u 5 godina. Po nalazima biopsije crijeva najviše djece pronađeno je sa stupnjem III po Marsh – Oberhuber klasifikaciji, njih 61 (48.03%), što je gotovo polovica ispitanika. Tip I celijakije pronađen je u 56 (44.09%), a tip II u 6 (4.72%) djece. Zaključak: Ovo istraživanje pokazalo je raspodjelu djece s novodijagnosticiranom celijakijom po spolu, medijanu i prosječnoj dobi bolesnika u trenutku postavljanja dijagnoze, tipu bolesti po Marsh – Oberhuberovoj klasifikaciji te je izračunata incidencija celijakije kod djece u našoj županiji. Pokazane su neke epidemiološke karakteristike celijakije u djece naše županije. Rezultati su uspoređeni s podacima iz drugih studija. Naše istraživanje potvrdilo je trend postavljanja dijagnoze celijakije u kasnijoj dobi djece. Također, izračunata incidencija u skladu je s dosadašnjim istraživanjima provedenim u Hrvatskoj i svijetu.Objective: The aim of this study was to specify the incidence of celiac disease at the Department of Pediatrics, University Hospital Centre Split from 2012 to 2016. Besides that the age of the patients at the time of the diagnosis and their gender were also researched as well as the number of patients in specific category of Marsh – Oberhuber classification. Materials and methods: This retrospective research included 127 examinees with newly diagnosed celiac disease. Examinees of both genders aged from 0 to 18 were included. The numbers of children affected were gathered by researching medical files of the Department of Pediatrics, University Hospital Centre Split. Each patient was analyzed according to age, gender and type of disease by Marsh – Oberhuber classification. The results were processed by descriptive (standard) statistic methods and presented through tables and graphs. Results: At the Department of Pediatrics, University Hospital Centre Split from January 1 2012 until December 31 2016, there have been total of 127 children newly diagnosed with celiac disease. Out of these, 71 (56%) was female and 56 (44%) was male. The median age of patients was 132 months (range: 5 to 213) and the average age was 120.9 months. Age distribution indicated that majority of children, 73 (57.48%) of them, were over 10 years old, 32 (25.2%) children were found in group from 0 to 6 years and remaining 22 (17.32%) in the 6 to 10 years of age. Calculated incidence for Split – Dalmatia County was 1.24/1000 which represents 124/100 000 children in the period of 5 years. According to results of small bowel biopsy, most children, 61 (48.03%) of them, have type III celiac disease by Marsh – Oberhuber classification which is almost the half of examinees. Type I was found in 56 (44.09%) of children and type II in 6 (4.72%) of children. Conclusion: This research has shown the distribution of children with newly diagnosed celiac disease according to gender, median of age and average age of the patients at the time of diagnosis as well as the type of the disease according to Marsh – Oberhuber classification. The incidence of celiac disease in Split – Dalmatia County was calculated. The results have shown some specific epidemiological characteristic of celiac disease in children in aforementioned county. The results have been compared to those of other studies. The research has confirmed the trend of late diagnostics of celiac disease. The calculated incidence is in accordance to the incidence calculated in other researches in Croatia and world