Non melanoma skin cancer

Non melanoma skin cancer is the most frequently occurring human malignancy. It is encountered all over the world, particularly in areas with high exposure to its primary risk factor, sunlight. The pathogenesis involves signature UV mutations in genes coding for tumor suppression and growth signalling. Early identification of suspicious lesions is significant because the various therapies available are most effective for localized disease. The elucidation of the MAPK and PI3K growth pathways in cutaneous squamous cell carcinoma and the Sonic Hedgehog signalling pathway in basal cell carcinoma have led to the development of novel treatments for metastatic disease