Preparation and characterization of biologically active ferrocene and uracil derivative

Kopulati ferocena s nukleobazama jednako kao i sa triazolima postaju sve češći predmet istraţivanja zbog svoje izuzetne biološke aktivnosti te su pronašli svoje mjesto u različitim granama kemije, posebice u medicinskoj kemiji gdje dolaze do izraţaja upravo zbog svojih bioloških svojstava kao što su antioksidativno, antikancerogeno, antimalarijsko djelovanje. Cilj ovog rada je priprava potencijalno biološki aktivnog kopulata uracila i ferocena povezanih preko 1,2,3-triazolne poveznice. Triazolni prsten je uveden reakcijom "klik kemije", odnosno 1,3-dipolarnom cikloadicijom ferocenskog azida i N-1-propargil uracila u prisutnosti katalizatora bakra. Struktura svih prireĎenih spojeva potvrĎena je IR i NMR spektroskopijom.Ferrocenoyl-nucleobase and ferrocenoyl-triazole derivates are becoming more common subject of research due to their exceptional biological activity. They have functions in different areas of chemistry, especially in medicinal chemistry where their biological properties such as their antioxidative, anticancer, antimalarial activities can be used. The aim of this work is to prepare a potentially biologically active compound of uracil and ferrocene derivatives linked via 1,2,3-triazole linkage. The triazole ring was introduced by the reaction of "click chemistry", i.e. 1,3-dipolar cycloaddition between ferrocenoyl azide and N-1propargil uracil in the presence of copper catalyst. The structure of all prepared compounds was confirmed by IR and NMR spectroscopy