Interaction of cadmium and essential microelements iron and zinc in non-pregnant and pregnant laboratory rats

Svrha rada bila je procijeniti učinke peroralne izloženosti kadmiju (50 ppm Cd u obliku klorida u piću) u štakorica izvan i tijekom graviditeta na razdiobu kadmija i esencijalnih mikroelemenata željeza i cinka u odraslih štakorica i fetusima. Izloženost je trajala tijekom 20 dana odnosno od 1. do 20. dana skotnosti. Mikrolementi u krvi, jetri i bubregu štakorica te u posteljicama i fetusima analizirani su atomskom apsorpcijskom spektrometrijom. U skotnih u odnosu na neskotne izložene štakorice bila su izraženija povećanja kadmija u krvi i unutarnjim organima te jača smanjenja željeza u jetri i bubrezima. Cink se povećao u jetri svih izloženih ženki, a smanjio u bubrezima skotnih izloženih štakorica. Nakupljanje kadmija u posteljici bilo je povezano sa smanjenjima cinka u posteljici i željeza u fetusima. U zaključku, supkronična izloženost kadmiju tijekom graviditeta remeti tkivne esencijalne mikroelemente jače nego izvan graviditeta i ometa njihov prijenos posteljicom do fetusa.The work aimed at assessing effects of oral cadmium exposure (50 ppm Cd as chloride in drink) in female rats out of and during pregnancy on cadmium and essential microelements iron and zinc distribution in adult rats and foetuses. Exposure lasted throughout 20 days or from day 1-20 of gestation. Microelements in rat blood, liver and kidney, and in placenta and foetuses were analysed by atomic absorption spectrometry. In pregnant in comparison to non-pregnant exposed rats were more pronounced both cadmium increases in blood and internal organs and iron decreases in the liver and kidney. In exposed rats, liver zinc increased in all, and kidney zinc decreased in pregnant rats. Cadmium accumulation in placenta was associated with decreases of placental zinc and foetal iron. In conclusion, cadmium exposure during pregnancy causes more perturbations in essential microelements in tissues than out of pregnancy, and disrupts their placental transport to the foetus