Binuclear polypyridine ruthenium compounds have been shown to slowly intercalate into DNA, following a fast initial binding on the DNA surface. For these compounds, intercalation requires threading of a bulky substituent, containing one RuII, through the DNA base-pair stack, and the accompanying DNA duplex distortions are much more severe than with intercalation of mononuclear compounds. Structural understanding of the process of intercalation may greatly gain from a characterisation of the initial interactions between binuclear RuII compounds and DNA. We report a structural NMR study on the binuclear RuII intercalator L,L-B (L,L-[m-bidppz- (bipy)4Ru2] 4+; bidppz=11,11’-bis(dipyrido[3,2-a:2’,3’-c]phenazinyl, bipy = 2,2’-bipyridine) mixed wi...
Herein we report the separation of the three stereoisomers of the DNA light-switch compound [{Ru(bpy...
The DNA binding geometries for a series of enantiomerically purr substitution-inert ruthenium(II) co...
Small molecules that interact with DNA through intercalation are attractive candidates for treatment...
Binuclear polypyridine ruthenium compounds have been shown to slowly intercalate into DNA, following...
In the long succession of small transition-metal compounds interacting reversibly with DNA, semirigi...
The binuclear ruthenium complex [mu-bidppz(phen)(4)Ru-2](4+) has been extensively studied since the ...
The Ru-complex Λ,Λ-[bidppz(bipy)4Ru2]4+ (Λ,Λ-B) exhibits multiple modes of interactions with the pal...
Studies on intercalation of bulky binuclear ruthenium compounds into DNA have attracted attention du...
Herein we report the separation of the three stereoisomers of the DNA light-switch compound [{Ru(bpy...
Ever since the discovery of the role of DNA as the template for protein synthesis, efforts have been...
<p>Binuclear ruthenium(II) complexes with a bidppz bridging ligand are known to display kinetic and ...
The slow dissociation of DNA threading intercalators makes them interesting as model compounds in th...
DNA intercalation by threading is expected to yield high affinity and slow dissociation, properties ...
Molecules that bind DNA via threading intercalation show high binding affinity as well as slow disso...
Herein we report the separation of the three stereoisomers of the DNA light-switch compound [{Ru(bp...
Herein we report the separation of the three stereoisomers of the DNA light-switch compound [{Ru(bpy...
The DNA binding geometries for a series of enantiomerically purr substitution-inert ruthenium(II) co...
Small molecules that interact with DNA through intercalation are attractive candidates for treatment...
Binuclear polypyridine ruthenium compounds have been shown to slowly intercalate into DNA, following...
In the long succession of small transition-metal compounds interacting reversibly with DNA, semirigi...
The binuclear ruthenium complex [mu-bidppz(phen)(4)Ru-2](4+) has been extensively studied since the ...
The Ru-complex Λ,Λ-[bidppz(bipy)4Ru2]4+ (Λ,Λ-B) exhibits multiple modes of interactions with the pal...
Studies on intercalation of bulky binuclear ruthenium compounds into DNA have attracted attention du...
Herein we report the separation of the three stereoisomers of the DNA light-switch compound [{Ru(bpy...
Ever since the discovery of the role of DNA as the template for protein synthesis, efforts have been...
<p>Binuclear ruthenium(II) complexes with a bidppz bridging ligand are known to display kinetic and ...
The slow dissociation of DNA threading intercalators makes them interesting as model compounds in th...
DNA intercalation by threading is expected to yield high affinity and slow dissociation, properties ...
Molecules that bind DNA via threading intercalation show high binding affinity as well as slow disso...
Herein we report the separation of the three stereoisomers of the DNA light-switch compound [{Ru(bp...
Herein we report the separation of the three stereoisomers of the DNA light-switch compound [{Ru(bpy...
The DNA binding geometries for a series of enantiomerically purr substitution-inert ruthenium(II) co...
Small molecules that interact with DNA through intercalation are attractive candidates for treatment...