Liver-derived igf-I regulates mean life span in mice
- Svensson, Johan
- Sj\uf6gren, Klara
- F\ue4ldt, Jenny
- Andersson, Niklas
- Isaksson, Olle
- Jansson, John-Olov
- Ohlsson, Claes
Publication date
January 2011
DOI Publisher
Public Library of Science (PLoS)Abstract
Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have increased longevity. This study investigated whether specific deficiency of liver-derived, endocrine IGF-I is of importance for life span
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