We investigate the dynamics of a wild-type viral strain which generates mutant strains differing in phenotypic properties for infectivity, virulence, and mutation rates. We study, by means of a mathematical model and bifurcation analysis, conditions under which the wild-type and mutant viruses, which compete for the same host cells, can coexist. The coexistence conditions are formulated in terms of the basic reproductive numbers of the strains, a maximum value of the mutation rate, and the virulence of the pathogens. The analysis reveals that parameter space can be divided into five regions, each with distinct dynamics, that are organised around degenerate Bogdanov-Takens and zero-Hopf bifurcations, the latter of which gives rise to a curve...
The infection of cells by multiple copies of a given virus can impact viral evolution in a variety o...
<div><p>This paper uses methods drawn from physics to study the life cycle of viruses. The paper ana...
International audienceAbstractDuring replication, RNA viruses accumulate genome alterations, such as...
We investigate the dynamics of a wild-type viral strain which generates mutant strains differing in ...
We investigate the dynamics of a wild-type viral strain which generates mutant strains differing in ...
Altres ajuts: CERCA Programme/Generalitat de CatalunyaWe investigate the dynamics of a wild-type vir...
We consider two viral strains competing against each other within individual hosts (at cellular leve...
We consider two viral strains competing against each other within individual hosts (at cellular leve...
In this work, we have investigated the evolutionary dynamics of a generalist pathogen, e.g., a virus...
This work is devoted to the study of persistence and evolution of two viruses in the host organism t...
In this work we have investigated the evolutionary dynamics of a generalist pathogen, e.g. a virus p...
RNA viruses exist as genetically diverse populations displaying a range of virulence degrees. The ev...
RNA viruses exist in large intra-host populations which display great genotypic and phenotypic diver...
RNA viruses exist as genetically diverse populations displaying a range of virulence degrees. The ev...
In this work, we develop a mathematical framework for predicting and quantifying virus diversity evo...
The infection of cells by multiple copies of a given virus can impact viral evolution in a variety o...
<div><p>This paper uses methods drawn from physics to study the life cycle of viruses. The paper ana...
International audienceAbstractDuring replication, RNA viruses accumulate genome alterations, such as...
We investigate the dynamics of a wild-type viral strain which generates mutant strains differing in ...
We investigate the dynamics of a wild-type viral strain which generates mutant strains differing in ...
Altres ajuts: CERCA Programme/Generalitat de CatalunyaWe investigate the dynamics of a wild-type vir...
We consider two viral strains competing against each other within individual hosts (at cellular leve...
We consider two viral strains competing against each other within individual hosts (at cellular leve...
In this work, we have investigated the evolutionary dynamics of a generalist pathogen, e.g., a virus...
This work is devoted to the study of persistence and evolution of two viruses in the host organism t...
In this work we have investigated the evolutionary dynamics of a generalist pathogen, e.g. a virus p...
RNA viruses exist as genetically diverse populations displaying a range of virulence degrees. The ev...
RNA viruses exist in large intra-host populations which display great genotypic and phenotypic diver...
RNA viruses exist as genetically diverse populations displaying a range of virulence degrees. The ev...
In this work, we develop a mathematical framework for predicting and quantifying virus diversity evo...
The infection of cells by multiple copies of a given virus can impact viral evolution in a variety o...
<div><p>This paper uses methods drawn from physics to study the life cycle of viruses. The paper ana...
International audienceAbstractDuring replication, RNA viruses accumulate genome alterations, such as...