The natural UV-screener scytonemin is found in a plethora of cyanobacterial species. Its UV-protective ability allows the bacteria to thrive in inhospitable locations exposed to intense solar radiation. Scytonemin has a dimeric structure consisting of two 1-1\u27 linked 3-(4-hydroxybenzylidene)cyclopenta[b]indole-2-one moieties. The cyanobacterial pigment nostodione A consists of the same skeleton, but is not symmetrically appended at C-1. Instead it appears as a 1,2-dione. Both natural products have displayed attractive bioactivity, e.g. inhibition of cancer cell mitosis and in vitro reduction of kinase activity. In this study, flexible synthetic strategies leading to the 3-alkenyl-cyclopenta[b]indole-2-one skeleton have been investigated,...
As phototrophic bacteria, cyanobacteria are continually exposed to ultraviolet radiation as they har...
Tyrosinase, an important oxidase involved in the primary immune response in humans, can sometimes be...
As phototrophic bacteria, cyanobacteria are continually exposed to ultraviolet radiation as they har...
The natural UV-screener scytonemin is found in a plethora of cyanobacterial species. Its UV-protecti...
Natural product synthesis is an exciting field of organic chemistry, directed toward constructing na...
Scytonemin is a promising UV-screen and antioxidant small molecule with commercial value in cosmetic...
Scytonemin and nostodione A are cyanobacteria sunscreen pigments that have interesting biological pr...
The first total synthesis of the mitotic spindle poison nostodione A is described. The inherent oxid...
Depletion of the stratospheric ozone layer is increasing the level of harmful ultraviolet (UV) radia...
Scytonemin is a 544-Da hydrophobic pigment that can absorb UV-A radiation. It is present in cyanobac...
As a part of their sun-protective strategy, cyanobacteria produce the natural UV-screener scytonemin...
Under exposure to long-wavelength ultraviolet radiation (UVA), some cyanobacteria can produce scyton...
Previous studies of the biosynthetic enzymes involved in the assembly of scytonemin (1), a cyanobact...
Following exposure to long-wavelength ultraviolet radiation (UVA), some cyanobacteria produce the in...
Cyanobacteria are photosynthesizing organisms that live in environments open to solar ultraviolet ra...
As phototrophic bacteria, cyanobacteria are continually exposed to ultraviolet radiation as they har...
Tyrosinase, an important oxidase involved in the primary immune response in humans, can sometimes be...
As phototrophic bacteria, cyanobacteria are continually exposed to ultraviolet radiation as they har...
The natural UV-screener scytonemin is found in a plethora of cyanobacterial species. Its UV-protecti...
Natural product synthesis is an exciting field of organic chemistry, directed toward constructing na...
Scytonemin is a promising UV-screen and antioxidant small molecule with commercial value in cosmetic...
Scytonemin and nostodione A are cyanobacteria sunscreen pigments that have interesting biological pr...
The first total synthesis of the mitotic spindle poison nostodione A is described. The inherent oxid...
Depletion of the stratospheric ozone layer is increasing the level of harmful ultraviolet (UV) radia...
Scytonemin is a 544-Da hydrophobic pigment that can absorb UV-A radiation. It is present in cyanobac...
As a part of their sun-protective strategy, cyanobacteria produce the natural UV-screener scytonemin...
Under exposure to long-wavelength ultraviolet radiation (UVA), some cyanobacteria can produce scyton...
Previous studies of the biosynthetic enzymes involved in the assembly of scytonemin (1), a cyanobact...
Following exposure to long-wavelength ultraviolet radiation (UVA), some cyanobacteria produce the in...
Cyanobacteria are photosynthesizing organisms that live in environments open to solar ultraviolet ra...
As phototrophic bacteria, cyanobacteria are continually exposed to ultraviolet radiation as they har...
Tyrosinase, an important oxidase involved in the primary immune response in humans, can sometimes be...
As phototrophic bacteria, cyanobacteria are continually exposed to ultraviolet radiation as they har...