International audienceBackground:Obtaining atomic-scale information about large-amplitude conformational transitions in proteins is achallenging problem for both experimental and computational methods. Such information is, however, importantfor understanding the mechanisms of interaction of many proteins.Methods:This paper presents a computationally efficient approach, combining methods originating from roboticsand computational biophysics, to model protein conformational transitions. The ability of normal mode analysis topredict directions of collective, large-amplitude motions is applied to bias the conformational explorationperformed by a motion planning algorithm. To reduce the dimension of the problem, normal modes arecomputed for a co...
Large-scale conformational changes are essential for proteins to function properly. Given that these...
The biological function of proteins is closely related to its structural motion. For instance, struc...
The biological function of proteins is closely related to its structural motion. For instance, struc...
International audienceBackground:Obtaining atomic-scale information about large-amplitude conformati...
International audienceThis paper presents a method, inspired by robot motion planning algorithms, to...
International audienceThis paper presents a method, inspired by robot motion planning algorithms, to...
International audienceKEYWORDS Protein flexibility, large-amplitude conformational transitions, elas...
International audienceKEYWORDS Protein flexibility, large-amplitude conformational transitions, elas...
We report the development of a method to improve the sampling of protein conformational space in mol...
We report the development of a method to improve the sampling of protein conformational space in mol...
Abstract. Protein function frequently involves conformational changes with large amplitude on time s...
Protein function frequently involves conformational changes with large amplitude on timescales which...
We present a novel sampling approach to explore large protein conformational transitions by determin...
AbstractIn this article, we apply a coarse-grained elastic network model (ENM) to study conformation...
AbstractWe present a novel sampling approach to explore large protein conformational transitions by ...
Large-scale conformational changes are essential for proteins to function properly. Given that these...
The biological function of proteins is closely related to its structural motion. For instance, struc...
The biological function of proteins is closely related to its structural motion. For instance, struc...
International audienceBackground:Obtaining atomic-scale information about large-amplitude conformati...
International audienceThis paper presents a method, inspired by robot motion planning algorithms, to...
International audienceThis paper presents a method, inspired by robot motion planning algorithms, to...
International audienceKEYWORDS Protein flexibility, large-amplitude conformational transitions, elas...
International audienceKEYWORDS Protein flexibility, large-amplitude conformational transitions, elas...
We report the development of a method to improve the sampling of protein conformational space in mol...
We report the development of a method to improve the sampling of protein conformational space in mol...
Abstract. Protein function frequently involves conformational changes with large amplitude on time s...
Protein function frequently involves conformational changes with large amplitude on timescales which...
We present a novel sampling approach to explore large protein conformational transitions by determin...
AbstractIn this article, we apply a coarse-grained elastic network model (ENM) to study conformation...
AbstractWe present a novel sampling approach to explore large protein conformational transitions by ...
Large-scale conformational changes are essential for proteins to function properly. Given that these...
The biological function of proteins is closely related to its structural motion. For instance, struc...
The biological function of proteins is closely related to its structural motion. For instance, struc...