Synthesis of biologically active cyclic derivatives of 5(6)-amino substituted benzimidazoles

U okviru ovog rada provedena je sinteza acikličkog 2-benzimidazolil supstituiranog akrilonitrila 6 te njegovog cikličkog analoga benzimidazo[1,2-a]kinolina 7. Spojevi su priređeni klasičnim reakcijama organske sinteze te aminacijom potpomognutom mikrovalnim zračenjem. Benzimidazolil-supstituirani akrilonitril 6 priređen iz 2-cijanometil-5(6)- piperidinilbenzimidazola 4 i o-klorbenzaldehida 5, dok je benzimidazo[1,2-a]kinolin 7 priređen termičkom ciklizacijom akrilonitrila 6 u sulfolanu pri čemu je dobivena smjesa dva regioizomera. Strukture priređenih spojeva potvrđene su 1H i 13C NMR spektroskopijom. Spojevi 3-7 okarakterizirani su UV/Vis i fluormetrijskom spektroskopijom.This work presents the synthesis of novel 2-benzimidazolyil-substituted acrylonitrile 6 and it's cyclic analog, benzimidazo[1,2-ɑ]qinoline 7. Novel compounds were prepared by using a classical reactions of organic chemistry and microwave assisted amination. Benzimidazolyilsubstituted acrylonitrile 6 was prepared in reaction of 2-cyanomethyl-5(6)- piperidinylbenzimidazole 4 with o-chlorobenzaldehyde 5. Benzimidazo[1,2-ɑ]quinoline 7 was prepared by thermal cyclization of acrylonitrile 6 in sulfolane as a mixture of two regioisomers. The structures of all compounds were determined by means of 1H and 13C NMR and UV/Vis and fluorimetric spectroscopy